Results 161 to 170 of about 316,105 (288)

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

PDCD5 Contributes to Airway Epithelial Cell Damage via Mitochondrial Pathway and Participates in COPD Pathogenesis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Airway epithelial injury plays a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Mitochondrial dysfunction is implicated in this injury, while the underlying mechanism remains incompletely understood. RNA sequencing was conducted to identify key genes involved in mitochondrial dysfunction in airway epithelial
Hu Shan, Rui Zhang, Yu‐er Li, Rui Li, Shao‐bo Ge, Jin Liu, Shi‐yuan Yao, Xia Yang, Tao Zhang, Ming Zhang   +9 more
wiley   +1 more source

Beyond the neuron: Exosomes as intercellular modulators of mitochondrial networks in the pathogenesis and treatment of Alzheimer's disease. [PDF]

Alzheimers Dement
Xing L, Liu A, Gao W, Li J, Yao M, Song J, Duan P, Li H.   +7 more
europepmc   +1 more source

Inflammation, Immunity, and Cardiovascular Diseases

Med Research, EarlyView.
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo, Yan Liao, Rui Zhao, Zhaoyu Li, Kaikai Wang, Haoling Zhang, Pingxin Sun, Yadong Guo, Wangzheqi Zhang   +8 more
wiley   +1 more source

Mitochondrial dysfunction, neuroinflammation, and associated mechanisms in sepsis-associated encephalopathy: from pathogenesis to emerging therapeutics. [PDF]

Front Neurosci
Shen Y, Ye XM, Li PY, Chen SL.
europepmc   +1 more source

Quantification of 10B and 11B in Biological Samples in Translational Science and Clinical Applications for Boron Neutron Capture Therapy (BNCT)

Medicinal Research Reviews, EarlyView.
ABSTRACT Boron neutron capture therapy (BNCT) is a targeted radiotherapy that exploits the selective accumulation of the 10B isotope within tumors, followed by irradiation with low‐energy neutrons to induce high linear energy transfer particles with short path lengths, resulting in localized tumor cell destruction while sparing surrounding healthy ...
Christoph Selg, Wolfgang A. G. Sauerwein, Evamarie Hey‐Hawkins   +2 more
wiley   +1 more source

Mitochondrial homeostasis: the central hub governing the progression of atherosclerosis. [PDF]

Precis Clin Med
Liu H, Zhao S, Gao H, Wang Y, Gao J, Guo P, Yang Y, Cui W, Zhang S, Shi Y, Xie G, Han Y, Zhou J, Zhang Q, Zou Y.   +14 more
europepmc   +1 more source

Recent Advances in the Laser‐Based Fabrication and Applications of High‐Entropy Alloy Nanoparticles

MetalMat, EarlyView.
This review presents recent advances in the laser‐based fabrication of high‐entropy alloy nanoparticles, focusing on scalable, environmentally friendly, and compositionally tunable synthesis methods. It highlights the critical influence of laser parameters on nanoparticle size, phase, and morphology, enabling tailored properties for applications in ...
Bibek Kumar Singh, Rajesh Rawat, Archana Tiwari, Venugopal Rao Soma, Ajay Tripathi   +4 more
wiley   +1 more source

Schisandrol B protects against lithocholic acid-induced cholestatic liver injury in mice through mitochondrial biogenesis. [PDF]

Chin Med
Yang X, Liang H, Li X, Tian J, Fan S, Huang M, Wan J, Zuo Z, Guo H, Bi H.   +9 more
europepmc   +1 more source

The Weak Core, Partition‐Based Universal Stability, and Their Risk Associations Through A Partial Order

Naval Research Logistics (NRL), EarlyView.
ABSTRACT We are concerned with the stability of a transferable‐utility cooperative (TU) game. First, the concept of core can be weakened so that the blocking of changes is limited to only those with multilateral backings. This principle of consensual blocking, as well as the traditional core‐defining one of unilateral blocking and one straddling in ...
Jian Yang
wiley   +1 more source