Results 131 to 140 of about 20,584 (276)
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna +5 more
wiley +1 more source
Intermolecular Interactions and their Implications in Solid-State Photon Interconversion
Photon interconversion promises to alleviate thermalization losses for high energy photons and facilitates utilization of sub-bandgap photons – effectively enabling the optimal use of the entire solar spectrum.
Lea Nienhaus
doaj +1 more source
Prompt neutron fission spectrum mean energies for the fissile nuclides and /sup 252/Cf [PDF]
The international standard for a neutron spectrum is that produced from the spontaneous fission of /sup 252/Cf, while the thermal neutron induced fission neutron spectra for the four fissile nuclides, /sup 233/U, /sup 235/U, /sup 239/Pu, and /sup 241/Pu ...
Holden, Norman E.
core
Proteostasis of organelles in aging and disease
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
GCN2 in proteostasis: structural logic, signalling networks and disease
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source
Long‐read sequencing‐based atlas of tissue‐specific expression of DNM1L transcript variants
Targeted long‐read sequencing resolves full‐length DNM1L (Drp1) isoforms and reveals conserved, tissue‐specific expression patterns across human and mouse tissues. Functional assays show that Drp1 isoforms differ in their ability to drive mitochondrial fission, independent of abundance, with specific exons modulating activity.
Feng Yan +19 more
wiley +1 more source
Bacteriophages—viruses that kill bacteria—are promising weapons against bacterial biofilms: sessile communities notoriously resistant to antibiotics. Yet phages evolved not so much to eradicate bacteria as to obtain new bacteria to infect. That goal, however, may conflict with the physician's objective of complete bacterial clearance.
Stephen T. Abedon
wiley +1 more source
Recent Measurements of the Prompt Neutron Emission Spectrum from Neutron-induced Fission of 235U [PDF]
Following a recommendation of the NEA Working Party on Evaluation cooperation (WPEC) the prompt fission neutron spectrum (PFNS) was measured during three measurement campaigns at an incident neutron energy En = 0.5 MeVJRC.D.5 - Neutron ...
HAMBSCH Franz-Josef +4 more
core
Methods to Study Mitochondrial Metabolism and Homeostasis in Fission Yeast
Yeast, EarlyView.
Ferran Gómez‐Armengol +2 more
wiley +1 more source
Noble gases and nitrogen in material from asteroid Bennu
Abstract We report the elemental and isotopic abundances of all stable noble gases (helium, neon, argon, krypton, and xenon) in eight particles from asteroid Bennu returned by NASA's OSIRIS‐REx mission. We also report nitrogen abundances and isotopic ratios that were analyzed alongside neon and argon in four additional Bennu particles.
B. Marty +7 more
wiley +1 more source

