Results 41 to 50 of about 1,538,596 (280)

Metastable Evolutionary Dynamics: Crossing Fitness Barriers or Escaping via Neutral Paths?

, 1999
We analytically study the dynamics of evolving populations that exhibit metastability on the level of phenotype or fitness. In constant selective environments, such metastable behavior is caused by two qualitatively different mechanisms. One the one hand,
Crutchfield, James P., van Nimwegen, Erik   +1 more
core   +1 more source

Relationship between behavioral-related variables and dental caries prevalence among university students: a cross-sectional study

Frontiers in Public Health
ObjectivesTo examine the association between behavioral-related variables (physical activity, BMI, dental check-ups) and dental caries prevalence among university students.MethodsA cross-sectional study was conducted among 2,322 university students using
Jiaxin Chen, Xiaoxiao Chen, Chunmiao Wang, Deqiang Zhao, Yanfeng Zhang   +4 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

On The Structure of Competitive Societies [PDF]

, 2005
We model the dynamics of social structure by a simple interacting particle system. The social standing of an individual agent is represented by an integer-valued fitness that changes via two offsetting processes.
Ben-Naim, E., Redner, S., Vazquez, F.
core   +3 more sources

Fitness technology

Physical Culture Sport Tourism Motor Recreation, 2023
The author examines the trends in the development of fitness in the cities of Russia. Analyzes the factors behind the increased popularity of fitness and describes popular and new types of this direction. Relevance. Sports are essential for every person. It is fitness areas that have become popular for the vast majority of Russians, as they have a wide
V. D. Ivanov, O. V. Marandykina
openaire   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

What could be the reasons for not losing weight even after following a weight loss program?

Journal of Health, Population and Nutrition
Introduction Approximately four million people worldwide die annually because of obesity. Weight loss is commonly recommended as a first-line therapy in overweight and obese patients.
Jyoti Dabas, S. Shunmukha Priya, Akshay Alawani, Praveen Budhrani   +3 more
doaj   +1 more source

Exercise Training Upregulates Cardiac mtp Expression in Drosophila melanogaster with HFD to Improve Cardiac Dysfunction and Abnormal Lipid Metabolism

Biology, 2022
Current evidence suggests that the heart plays an important role in regulating systemic lipid homeostasis, and high-fat diet (HFD)-induced obesity is a major cause of cardiovascular disease, although little is known about the specific mechanisms involved.
Tianhang Peng, Meng Ding, Hanhui Yan, Qiufang Li, Ping Zhang, Rui Tian, Lan Zheng   +6 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Adaptive evolution of molecular phenotypes

, 2014
Molecular phenotypes link genomic information with organismic functions, fitness, and evolution. Quantitative traits are complex phenotypes that depend on multiple genomic loci. In this paper, we study the adaptive evolution of a quantitative trait under
Armita Nourmohammad, Chernyak V Y, Crow J F, Falconer D S, Fisher R, Lynch M, Lynch M, Lynch M, Michael Lässig, Muller H J, Neher R A, Nourmohammad A, Nourmohammad A, Torsten Held   +13 more
core   +1 more source