Results 71 to 80 of about 114,985 (325)
Inverse Feature Learning: Feature Learning Based on Representation Learning of Error
IEEE Access, 2020 This paper proposes inverse feature learning (IFL) as a novel supervised feature learning technique that learns a set of high-level features for classification based on an error representation approach. The key contribution of this method is to learn the
Behzad Ghazanfari +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Local factorizations of nonlocal fitting classes [PDF]
, 2008 We consider general rules of constructing of local products of the Fitting classes with the use of nonlocal factors determined by the minimal elements of the Lockett section. We give a simple method to construct local Fitting classes which are factorised
Vorob`ev, N. N. +2 more
core
Physical Review Physics Education Research, 2022 Physics classes with computation integrated into the curriculum are a fitting setting for investigating computational thinking. In this paper, we present a framework for exploring this topic in introductory physics courses.
Daniel P. Weller +3 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
On Modular Property for Fitting Classes [PDF]
, 2004 The article discusses modular Property for Fitting ...
Yu Qiu, Liu Yu-Feng
core
A Certain Class of Tests of Fit
The Annals of Mathematical Statistics, 1956 Suppose $X_1, X_2, \cdots, X_n$ are known to be independently and identically distributed, each with the density function $f(x),$ with $\int^1_0f(x) dx = 1.$ Let $Y_1 \leqq Y_2 \leqq \cdots \leqq Y_n$ be the ordered values of $X_1, X_2, \cdots, X_n,$ and define $W_1 = Y_1, W_2 = Y_2 - Y_1, \cdots, W_n = Y_n - Y_{n -1},$ and $W_{n + 1} = 1 - Y_n,$ so ...
openaire +3 more sources
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source