Results 91 to 100 of about 114,985 (325)

Estimação de parâmetros genéticos para produção de leite de cabras da raça Alpina Genetic parameters estimation for test day milk yield of Alpina goats

open access: yesRevista Brasileira de Zootecnia, 2006
Foram utilizados 9.374 registros semanais de produção de leite de 302 primeiras lactações de cabras da raça Alpina. A produção de leite no dia do controle foi analisada por meio de um modelo animal, unicarater, de regressão aleatória, em que as funções ...
Fernanda Cristina Breda   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Modeling of secondary organic aerosol yields from laboratory chamber data [PDF]

open access: yesAtmospheric Chemistry and Physics, 2009
Laboratory chamber data serve as the basis for constraining models of secondary organic aerosol (SOA) formation. Current models fall into three categories: empirical two-product (Odum), product-specific, and volatility basis set. The product-specific and
M. N. Chan   +4 more
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

On the theory of Fitting classes of finite soluble groups [PDF]

open access: yes, 1970
Wir betrachten in der vorliegenden Arbeit Fittingklassen X endlicher aufloesbarer Gruppen, deren Injektoren lokal, d.h. in allen zu einer X umfassenden Fittingklasse F < S gehoerenden Gruppen, eine gegebene Einbettungseigenschaft besitzen ...
Reifferscheid, Stephanie
core  

Lockett Hypothesis for Products of Fitting Classes of Finite Groups [PDF]

open access: yes, 2016
О новых работах классов Фиттинга, которые не являются классами Локетта и удовлетворяют гипотезе Локетта = On new works Fitting classes which are not classes of Lockett and satisfy hypothesis of ...
Залесская, Е. Н.
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Intimate partner violence in Nepal: Latent patterns and association with depressive symptoms

open access: yesSSM: Population Health, 2019
Existing data suggest that there are distinct patterns (or classes) of intimate partner violence (IPV) experience that depart from dichotomous categorizations used to monitor progress toward Sustainable Development Goal 5.2.
Cari Jo Clark   +6 more
doaj   +1 more source

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