Results 101 to 110 of about 114,985 (325)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

On modularity property of the lattice of partially composition Fitting classes [PDF]

open access: yes, 2021
In this paper the sufficient conditions of the modularity of the lattice of all partially composition Fitting classes were ...
Vorob’ev, N. N.   +2 more
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

IntLevPy: A Python library to classify and model intermittent and Lévy processes

open access: yesSoftwareX
IntLevPy provides a comprehensive description of the IntLevPy Package, a Python library designed for simulating and analyzing intermittent and Lévy processes. The package includes functionalities such as full parameter estimation and fitting optimization
Shailendra Bhandari   +4 more
doaj   +1 more source

DYNAMIC BAYESIAN NETWORK FOR WEATHER FORECAST AND EVALUATION OF RENEWABLE RESOURCES AVAILABILITY [PDF]

open access: yesJournal of Sustainable Energy, 2018
The authors present a Bayesian network capable to estimate the weather parameters related, not only, to renewable resources: wind speed and solar irradiation.
CIOBANU A.   +3 more
doaj  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Enjoy the Joy of Copulas: With a Package copula

open access: yesJournal of Statistical Software, 2007
Copulas have become a popular tool in multivariate modeling successfully applied in many fields. A good open-source implementation of copulas is much needed for more practitioners to enjoy the joy of copulas.
Jun Yan
doaj  

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