Results 121 to 130 of about 114,985 (325)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
On the theory of fitting classes of finite soluble groups [PDF]
We continue the study Fitting classes begun by Fischer in 1966 and carried on by (notably) Gaschütz and Hartley. Disappointingly the theory has, as yet, failed to display the richness of its predecessor, the theory of Formations.
Lockett, Francis Peter
core
On stone sublattice of the lattice of totally local Fitting classes [PDF]
, 2007 Totally local Fitting classes with a Stone lattice of totally local Fitting subclasses are ...
Skiba, A. N., Vorob`ev, N. N.
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Multi-class Model Fitting by Energy Minimization and Mode-Seeking [PDF]
, 2018 Dániel Baráth, Jiřı́ Matas
openalex +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 1988 A generalized notion of Fitting pairs is introduced and made concrete by giving a construction scheme for Fitting classes that leads to some well-known Fitting class constructions as easy special cases.
Pense, Joachim
core +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
‘Fitting in’ or ‘standing out’: Working‐class students in UK higher education [PDF]
, 2009 Diane Reay, Gill Crozier, John Clayton
openalex +1 more source