Results 81 to 90 of about 114,985 (325)
BMC Medical Research Methodology, 2020 Background Growth Mixture Modeling (GMM) is commonly used to group individuals on their development over time, but convergence issues and impossible values are common. This can result in unreliable model estimates. Constraining variance parameters across
Jitske J. Sijbrandij +5 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Beyond Drift Diffusion Models: Fitting a broad class of decision and RL models with HDDM [PDF]
, 2022 Alexander Fengler +3 more
openalex +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Embroidered Fittings — “Middle Class” Jewelry of the Old Russian Time? [PDF]
, 2021 Vladislav Sobolev
openalex +1 more source
Problems related to the Lockett Conjecture on Fitting classes [PDF]
, 2008 The existence of a solvable non-normal Fitting class F which is not a Lockett class but for which the Lockett Conjecture still holds are studied. We also prove that there exists an ω-local Fitting class F which does not satisfy the Lockett conjecture but
Wenbin, Guo, Vorob`ev, N. T.
core
The lattice of Fitting classes which are right extensible by soluble groups
, 2021 In this paper we study the set of Fitting classes which are right extensible by soluble groups ordered by the inclusion relation. The consideration of the associated lattices gives rise to new Fitting classes and it allows to obtain some injectivity ...
Lafuente, J. P. +2 more
core
LandA clean environment is an essential component of sustainable development, which is based on a comprehensive understanding of the behavior of water, soil, and air.
Ali Rasoulzadeh +3 more
doaj +1 more source