Results 31 to 40 of about 3,137 (254)

Multi-axis synchronous interpolation feed rate adaptive planning with rotational tool center point function under comprehensive constraints

Advances in Mechanical Engineering, 2017
Real-time nonlinear error caused by rotation axis motion in five-axis interpolation can be compensated by rotational tool center point function.
Zhongquan Shi, Wenhua Ye, Ruijun Liang
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A Multidimensional Performance Evaluation Method for Blade‑Specialized Five‑Axis Machining Centers

Nanjing Hangkong Hangtian Daxue Xuebao
Machining of aero‑engine blade‑type complex curved‑surface parts places stringent requirements for high accuracy， stability， and efficiency on five‑axis CNC machine tools. To assess the suitability of domestic five‑axis CNC equipment for this application，
LIN Zhiqiang, LU Chengbin, LI Jia, ZHANG Jiacheng, WU Qixun, ZHAO Guolong   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Multi-dimensional force tracking-loading simulator development and simulation experiment for five-axis machining center

Advances in Mechanical Engineering
Aiming at the problems of insufficient loading dimension and difficult engineering application of CNC machine tool reliability test device, a low-cost, recyclable multi-dimensional force tracking-loading simulator is developed based on the conical test ...
Junjian Wang, Xianchao Wang, Jianghong Sun, Qinzhi Zhao, Xiaoan Chen, Naizheng Li, Hui Li, Xiao Yang   +7 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Consideration of optimizing rib shape for small size and high strength spiral bevel gear fabricated by five axis controlled machining center

Nihon Kikai Gakkai ronbunshu, 2019
We have developed a small size and high strength spiral bevel gear fabricated by five axis controlled machining center. In the present report, we propose a novel spiral bevel gear with the rib at the end of face width to reinforce the tooth bending ...
Shinya TOYOTA, Masahiro SAITO, Takashi SHIBATA, Toshiki HIROGAKI, Eiichi AOYAMA   +4 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

An attempt to relate dynamic tracking error to occurring situation based on additional rectilinear motion for five-axis machine tools

Advances in Mechanical Engineering, 2020
During five-axis CNC machining, the dynamic tracking error of the five-axis machine tool caused by imperfect servo dynamic performance is the major factor affecting the accuracy during high-speed and high-precision manufacturing.
Qicheng Ding, Jiexiong Ding, Jing Zhang, Li Du   +3 more
doaj   +1 more source

Research on nxug10.0 impeller automatic programming and DMU50 five axis machining center

Journal of Physics: Conference Series, 2021
Abstract Taking nxug10.0 software as the platform and impeller as an example, this paper analyzes the structural characteristics and processing difficulties of impeller, reasonably formulates the NC processing scheme, and uses nxug10.0 impeller processing module to plan the tool path, generate the tool path file, and simulate the ...
Xuanlin Ye, Ji Luo, Wu Zhang, Zou Zou
openaire   +1 more source