Results 51 to 60 of about 3,343 (256)

Multi-axis synchronous interpolation feed rate adaptive planning with rotational tool center point function under comprehensive constraints

Advances in Mechanical Engineering, 2017
Real-time nonlinear error caused by rotation axis motion in five-axis interpolation can be compensated by rotational tool center point function.
Zhongquan Shi, Wenhua Ye, Ruijun Liang
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Sensitivity Analysis in Ball Bar Measurement of Three-Dimensional Circular Movement Equivalent to Cone-Frustum Cutting in Five-Axis Machining Centers

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2013
The present paper describes the sensitivity coefficient of measurement in the three-dimensional circular interpolation movement that is equivalent to cone-frustum cutting in five-axis machining centers with a tilting rotary table. The sensitive direction
Noriyuki KATO, Masaomi TSUTSUMI, Yu TSUCHIHASHI, Ryuta SATO, Yukitoshi IHARA   +4 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

An attempt to relate dynamic tracking error to occurring situation based on additional rectilinear motion for five-axis machine tools

Advances in Mechanical Engineering, 2020
During five-axis CNC machining, the dynamic tracking error of the five-axis machine tool caused by imperfect servo dynamic performance is the major factor affecting the accuracy during high-speed and high-precision manufacturing.
Qicheng Ding, Jiexiong Ding, Jing Zhang, Li Du   +3 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

An integrated method for compensating and correcting nonlinear error in five-axis machining utilizing cutter contacting point data

Scientific Reports
In current five-axis computer numerical control (CNC) machining, the use of minute linear path segments as an approximation for the ideal cutter contacting (CC) point trajectory is still prevalent.
Liangji Chen, Haohao Xu, Qiang Huang, Pengcheng Wang   +3 more
doaj   +1 more source

Effect of CAD/CAM Post Process on S-Shaped Machining Test for Five-Axis Machining Center

International Journal of Automation Technology, 2019
ISO 10791-7, the test standard for machining centers, was revised in 2014 to add the test method for five-axis machining centers. However, an S-shaped test was additionally proposed as an accuracy test of aircraft parts from China immediately before the establishment of the test standard.
Yukitoshi Ihara, Koichiro Takubo, Tatsuo Nakai, Ryuta Sato   +3 more
openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source