Results 31 to 40 of about 3,132 (252)

Design of motion accuracy measurement device with three displacement sensors for machine tool and comparison of its setting method

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2014
The standard of test method for five-axis machining center is now under discussion by ISO. In its draft standard, the use of a measurement device with three displacement sensor is described in addition to the ball bar device that is well-known as the ...
Masashi YAMAJI, Naoki HAMABATA, Yukitoshi IHARA   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Multi-axis synchronous interpolation feed rate adaptive planning with rotational tool center point function under comprehensive constraints

Advances in Mechanical Engineering, 2017
Real-time nonlinear error caused by rotation axis motion in five-axis interpolation can be compensated by rotational tool center point function.
Zhongquan Shi, Wenhua Ye, Ruijun Liang
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A Multidimensional Performance Evaluation Method for Blade‑Specialized Five‑Axis Machining Centers

Nanjing Hangkong Hangtian Daxue Xuebao
Machining of aero‑engine blade‑type complex curved‑surface parts places stringent requirements for high accuracy， stability， and efficiency on five‑axis CNC machine tools. To assess the suitability of domestic five‑axis CNC equipment for this application，
LIN Zhiqiang, LU Chengbin, LI Jia, ZHANG Jiacheng, WU Qixun, ZHAO Guolong   +5 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Multi-dimensional force tracking-loading simulator development and simulation experiment for five-axis machining center

Advances in Mechanical Engineering
Aiming at the problems of insufficient loading dimension and difficult engineering application of CNC machine tool reliability test device, a low-cost, recyclable multi-dimensional force tracking-loading simulator is developed based on the conical test ...
Junjian Wang, Xianchao Wang, Jianghong Sun, Qinzhi Zhao, Xiaoan Chen, Naizheng Li, Hui Li, Xiao Yang   +7 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

An attempt to relate dynamic tracking error to occurring situation based on additional rectilinear motion for five-axis machine tools

Advances in Mechanical Engineering, 2020
During five-axis CNC machining, the dynamic tracking error of the five-axis machine tool caused by imperfect servo dynamic performance is the major factor affecting the accuracy during high-speed and high-precision manufacturing.
Qicheng Ding, Jiexiong Ding, Jing Zhang, Li Du   +3 more
doaj   +1 more source