Results 31 to 40 of about 3,343 (255)

Research on Key Technology of Online Measurement of Five-axis Linkage Machine Tool

Journal of Applied Science and Engineering
In order to improve the machining accuracy and online measurement accuracy of the five-axis linkage machine tool, the motion solution of the double pendulum head five-axis linkage machine tool is realized based on the analysis of the movement and change ...
Dashuang Wang, RongJing Hong
doaj   +1 more source

Fabrication of Edge Rounded Polylactic Acid Biomedical Stents by the Multi-Axis Micro-Milling Process

Applied Sciences, 2020
This paper presents the first try to fabricate degradable polylactic acid (PLA) biomedical stents with round edges by the multi-axis micro-milling process. Conventionally biomedical stents are produced by laser processing.
Fuh-Yu Chang, Yan-Chiau Chen, Te-Hsien Liang, Zong-Yan Cai   +3 more
doaj   +1 more source

A Multidimensional Performance Evaluation Method for Blade‑Specialized Five‑Axis Machining Centers

Nanjing Hangkong Hangtian Daxue Xuebao
Machining of aero‑engine blade‑type complex curved‑surface parts places stringent requirements for high accuracy， stability， and efficiency on five‑axis CNC machine tools. To assess the suitability of domestic five‑axis CNC equipment for this application，
LIN Zhiqiang, LU Chengbin, LI Jia, ZHANG Jiacheng, WU Qixun, ZHAO Guolong   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Multi-dimensional force tracking-loading simulator development and simulation experiment for five-axis machining center

Advances in Mechanical Engineering
Aiming at the problems of insufficient loading dimension and difficult engineering application of CNC machine tool reliability test device, a low-cost, recyclable multi-dimensional force tracking-loading simulator is developed based on the conical test ...
Junjian Wang, Xianchao Wang, Jianghong Sun, Qinzhi Zhao, Xiaoan Chen, Naizheng Li, Hui Li, Xiao Yang   +7 more
doaj   +1 more source

Design of motion accuracy measurement device with three displacement sensors for machine tool and comparison of its setting method

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2014
The standard of test method for five-axis machining center is now under discussion by ISO. In its draft standard, the use of a measurement device with three displacement sensor is described in addition to the ball bar device that is well-known as the ...
Masashi YAMAJI, Naoki HAMABATA, Yukitoshi IHARA   +2 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A geometric error tracing method based on the Monte Carlo theory of the five-axis gantry machining center

Advances in Mechanical Engineering, 2017
This article proposes a tracing method to identify key geometric errors for a computer numerical control machine tool by cutting an S-shaped test piece. Adjacent part relationships and machine tool errors transform relationships are described by topology
Jinwei Fan, Yuhang Tang, Dongju Chen, Changjun Wu   +3 more
doaj   +1 more source