Results 71 to 80 of about 1,241,383 (345)

A novel approach to decalcification in histopathology laboratory: An adaptation from the Hammersmith protocol

open access: yesIndian Journal of Pathology and Microbiology, 2019
Aim: Utility of modified Hammersmith protocol in the deacalcification and/or softening of tissues and samples in a histopathology laboratory were studied.
Prita Pradhan   +5 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Inferomedial cortical bone contact and fixation with calcar screws on the dynamic and static mechanical stability of proximal humerus fractures

open access: yesJournal of Orthopaedic Surgery and Research, 2019
BackgroundThis study aimed to explore the effect of retaining inferomedial cortical bone contact and fixation with calcar screws on the dynamic and static mechanical stability of proximal humerus fractures treated with a locking plate.MethodsTwelve ...
Xiaofeng Zhang   +8 more
semanticscholar   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Assessing the GRIP of Ventral Hernia Repair: How to Securely Fasten DIS Classified Meshes

open access: yesFrontiers in Surgery, 2018
Recurrences are frequently observed after ventral hernia repair. Based on clinical data, the mesh–defect area ratio (MDAR) can lead to lower recurrence rates.
Friedrich Kallinowski   +6 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Long-term effects of a one-time application of flue gas desulfurization gypsum on the soil pore structure in sodic paddy fields

open access: yesAgricultural Water Management
Saline–sodic soil suffer from a high content of exchangeable sodium ions in the soil colloid and the poor air and water permeability of the soil pore structure.
Jianzhong Guo   +9 more
doaj   +1 more source

Symbiotic Nitrogen Fixation and the Challenges to Its Extension to Nonlegumes

open access: yesApplied and Environmental Microbiology, 2016
Access to fixed or available forms of nitrogen limits the productivity of crop plants and thus food production. Nitrogenous fertilizer production currently represents a significant expense for the efficient growth of various crops in the developed world.
Florence Mus   +13 more
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

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