Results 1 to 10 of about 220,095 (281)

Active information requirements for fixation on the Wright-Fisher model of population genetics [PDF]

BIO-Complexity 2020(4):1-6, 2021
In the context of population genetics, active information can be extended to measure the change of information of a given event (e.g., fixation of an allele) from a neutral model in which only genetic drift is taken into account to a non-neutral model that includes other sources of frequency variation (e.g., selection and mutation).
Daniel Andrés Díaz Pachón, Robert J. Marks   +1 more
arxiv   +7 more sources

Fixation in Conditional Branching Process Models in Population Genetics [PDF]

Journal of Applied Probability, 2007
An alternative version of the necessary and sufficient condition for almost sure fixation in the conditional branching process model is derived. This formulation provides an insight into why the examples considered in Buckley and Seneta (1983) all have the same condition for fixation.
Thomas Prince, Neville C. Weber
  +5 more sources

POPULATION GENETICS, PLEIOTROPY, AND THE PREFERENTIAL FIXATION OF MUTATIONS DURING ADAPTIVE EVOLUTION [PDF]

Evolution, 2010
Ongoing debate centers on whether certain types of mutations are fixed preferentially during adaptive evolution. Although there has been much discussion, no quantitative framework currently exists to test for these biases. Here, we describe a method for distinguishing between the two processes that likely account for biased rates of substitution ...
Matthew A. Streisfeld, Mark D. Rausher
  +6 more sources

Phenotypic heterogeneity in modeling cancer evolution. [PDF]

PLoS ONE, 2017
The unwelcome evolution of malignancy during cancer progression emerges through a selection process in a complex heterogeneous population structure. In the present work, we investigate evolutionary dynamics in a phenotypically heterogeneous population of
Ali Mahdipour-Shirayeh, Kamran Kaveh, Mohammad Kohandel, Sivabal Sivaloganathan   +3 more
doaj   +10 more sources

Interplay between pleiotropy and secondary selection determines rise and fall of mutators in stress response. [PDF]

PLoS Computational Biology, 2010
Mutators are clones whose mutation rate is about two to three orders of magnitude higher than the rate of wild-type clones and their roles in adaptive evolution of asexual populations have been controversial.
Muyoung Heo, Eugene I Shakhnovich
doaj   +6 more sources

Fixation of mutators in asexual populations: the role of genetic drift and epistasis [PDF]

Evolution 67, 1143 (2013), 2012
We study the evolutionary dynamics of an asexual population of nonmutators and mutators on a class of epistatic fitness landscapes. We consider the situation in which all mutations are deleterious and mutators are produced from nonmutators continually at a constant rate.
Jain, K, Nagar, A
arxiv   +7 more sources

Reduction of a metapopulation genetic model to an effective one island model [PDF]

Europhys. Lett. 122, 18001 (2018), 2017
We explore a model of metapopulation genetics which is based on a more ecologically motivated approach than is frequently used in population genetics. The size of the population is regulated by competition between individuals, rather than by artificially imposing a fixed population size.
Alan J. McKane, Crow J. F., César Parra-Rojas, Gardiner C. W., Hanski I., Pielou E. C., van Kampen N. G., Wiggins S., Wright S.   +8 more
arxiv   +3 more sources

The propagation of a cultural or biological trait by neutral genetic drift in a subdivided population [PDF]

Theoretical Population Biology (2007) 71 454, 2006
We study fixation probabilities and times as a consequence of neutral genetic drift in subdivided populations, motivated by a model of the cultural evolutionary process of language change that is described by the same mathematics as the biological process.
Barton, Baxter, ben Avraham, Charlesworth, Cherry, Cox, Crow, Donnelly, Fisher, Gordon, Gradshteyn, Griffiths, Grimmett, Kelly, Kimura, Kingman, Latter, Lieberman, Maruyama, Maruyama, Moran, Möhle, Nagylaki, Nei, Nordborg, Notohara, Notohara, Peliti, R.A. Blythe, Rousset, Rousset, Rousset, Roze, Sjödin, Slatkin, Slatkin, Slatkin, Takahata, Trudgill, Wakeley, Wakeley, Wakeley, Wakeley, Wakeley, Wakeley, Whitlock, Whitlock, Wilkinson-Herbots, Wright   +48 more
arxiv   +3 more sources

Comparing newly developed SNP barcode panels with microsatellites to explore population genetics of malaria parasites in the Peruvian Amazon [PDF]

Frontiers in Genetics
IntroductionMalaria molecular surveillance (MMS) can provide insights into transmission dynamics, guiding national control programs. We previously designed AmpliSeq assays for MMS, which include different traits of interest (resistance markers and pfhrp2/
Luis Cabrera-Sosa, Luis Cabrera-Sosa, Luis Cabrera-Sosa, Mahdi Safarpour, Johanna Helena Kattenberg, Roberson Ramirez, Joseph M. Vinetz, Joseph M. Vinetz, Joseph M. Vinetz, Anna Rosanas-Urgell, Dionicia Gamboa, Dionicia Gamboa, Dionicia Gamboa, Dionicia Gamboa, Christopher Delgado-Ratto, Christopher Delgado-Ratto   +15 more
doaj   +2 more sources

A new method for ecologists to estimate heterozygote excess and deficit for multi‐locus gene families [PDF]

Ecology and Evolution
The fixation index, FIS, has been a staple measure to detect selection, or departures from random mating in populations. However, current Next Generation Sequencing (NGS) cannot easily estimate FIS, in multi‐locus gene families that contain multiple loci
Gabe D. O'Reilly, Oliver Manlik, Sandra Vardeh, Jennifer Sinclair, Belinda Cannell, Zachary P. Lawler, William B. Sherwin   +6 more
doaj   +2 more sources