Results 91 to 100 of about 5,625,610 (302)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Population Genetic Diversity of Two Marine Gobies (Gobiiformes: Gobiidae) from the North-Eastern Atlantic and the Mediterranean Sea

Journal of Marine Science and Engineering, 2020
Gobies (Gobiiformes: Gobiidae) are the most species-rich family of fishes in general, and the most abundant fish group in the European seas. Nonetheless, our knowledge on many aspects of their biology, including the population genetic diversity, is poor.
Katarína Čekovská, Radek Šanda, Kristýna Eliášová, Marcelo Kovačić, Stamatis Zogaris, Anna Maria Pappalardo, Tereza Soukupová, Jasna Vukić   +7 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The effects of recombination rate on the distribution and abundance of transposable elements [PDF]

, 2008
Transposable elements (TEs) often accumulate in regions of the genome with suppressed recombination. But it is unclear whether this pattern reflects a reduction in the efficacy of selection against deleterious insertions or a relaxation of ectopic ...
Charlesworth, Brian, Dolgin, Elie S.
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

The Moran model of population genetics : case studies with recombination and selection [PDF]

, 2012
Hustedt T. The Moran model of population genetics : case studies with recombination and selection. Bielefeld: Universität Bielefeld; 2012.The Moran model is a widespread model for a finite population in the field of population genetics.
Hustedt, Thiemo
core  

Heterogeneous Adaptive Trajectories of Small Populations on Complex Fitness Landscapes [PDF]

, 2008
Background Small populations are thought to be adaptively handicapped, not only because they suffer more from deleterious mutations but also because they have limited access to new beneficial mutations, particularly those conferring large benefits ...
J Arjan G M de Visser, Handel, Andreas, de Visser, J. Arjan G M, Habets, M.G.J.L., Michelle G J L Habets, Andreas Handel, Handel, A., Visser, J.A.G.M., de, de Visser, J.A.G.M., Habets, Michelle G J L, Daniel E Rozen, Rozen, Daniel E., Rozen, D.E.   +12 more
core   +2 more sources

Non-Mendelian Single-Nucleotide Polymorphism Inheritance and Atypical Meiotic Configurations are Prevalent in Hop

The Plant Genome, 2017
Hop ( L.) breeding programs seek to exploit genetic resources for bitter flavor, aroma, and disease resistance. However, these efforts have been thwarted by segregation distortion including female-biased sex ratios.
Dong Zhang, Katherine A. Easterling, Nicholi J. Pitra, Mark C. Coles, Edward S. Buckler, Hank W. Bass, Paul D. Matthews   +6 more
doaj   +1 more source

Fixation Time for Competing Beneficial Mutations and Their Genomic Footprint

Biology
Simple Summary Knowing how fast natural selection can act on changes in the environment is fundamental for understanding evolution. The time it takes for a beneficial mutation to spread through a natural population has been investigated thoroughly in the
Wolfgang Stephan
semanticscholar   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source