Results 101 to 110 of about 317,820 (317)
Some Consequences of Demographic Stochasticity in Population Genetics
Genetics, 2010 Much of population genetics is based on the diffusion limit of the Wright–Fisher model, which assumes a fixed population size. This assumption is violated in most natural populations, particularly for microbes.
T. Parsons, C. Quince, J. Plotkin
semanticscholar +1 more source
Molecular Oncology, EarlyView.Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran +16 more
wiley +1 more source
Intrinsic adaptive value and early fate of gene duplication revealed by a bottom-up approach
eLife, 2018 The population genetic mechanisms governing the preservation of gene duplicates, especially in the critical very initial phase, have remained largely unknown.
Guillermo Rodrigo, Mario A Fares
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Frontiers in Marine Science, 2020 Skipjack tuna (Katsuwonus pelamis) has historically been considered panmictic at the ocean basin scale because of the species’ life history and substantial absolute population size.
Giulia Anderson +9 more
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Probability of fixation of an advantageous mutant in a viral quasispecies [PDF]
Genetics 163:457-466, 2003, 2002 The probability that an advantageous mutant rises to fixation in a viral quasispecies is investigated in the framework of multi-type branching processes. Whether fixation is possible depends on the overall growth rate of the quasispecies that will form if invasion is successful, rather than on the individual fitness of the invading mutant.
arxiv
Average time until fixation of a mutant allele in a given population [PDF]
, 2010 One of the important problems in population genetics is how long it takes for a gene to go to fixation (become established). A mutant gene in a given population will eventually be lost or established.
Messan, Komi
core
Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer
Molecular Oncology, EarlyView.This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu +7 more
wiley +1 more source
Protein evolution depends on multiple distinct population size parameters
BMC Evolutionary Biology, 2018 That population size affects the fate of new mutations arising in genomes, modulating both how frequently they arise and how efficiently natural selection is able to filter them, is well established.
Alexander Platt +2 more
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Fixation probability of rare nonmutator and evolution of mutation rates [PDF]
Ecology and Evolution 6, 755-764 (2016), 2015 Although mutations drive the evolutionary process, the rates at which the mutations occur are themselves subject to evolutionary forces. Our purpose here is to understand the role of selection and random genetic drift in the evolution of mutation rates, and we address this question in asexual populations at mutation-selection equilibrium neglecting ...
arxiv
Alternative to the diffusion equation in population genetics.
Physical review. E, Statistical, nonlinear, and soft matter physics, 2010 Since its inception by Kimura in 1955 [M. Kimura, Proc. Natl. Acad. Sci. U.S.A. 41, 144 (1955)], the diffusion equation has become a standard technique of population genetics. The diffusion equation is however only an approximation, valid in the limit of
B. Houchmandzadeh, M. Vallade
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