Results 51 to 60 of about 141,341 (274)

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

A new method for ecologists to estimate heterozygote excess and deficit for multi‐locus gene families

Ecology and Evolution
The fixation index, FIS, has been a staple measure to detect selection, or departures from random mating in populations. However, current Next Generation Sequencing (NGS) cannot easily estimate FIS, in multi‐locus gene families that contain multiple loci
Gabe D. O'Reilly, Oliver Manlik, Sandra Vardeh, Jennifer Sinclair, Belinda Cannell, Zachary P. Lawler, William B. Sherwin   +6 more
doaj   +1 more source

Development and characterization of microsatellite markers for Antennaria corymbosa (Asteraceae) and close relatives

Applications in Plant Sciences, 2019
Premise The genus Antennaria has a complex evolutionary history due to dioecism, excessive polyploidy, and the evolution of polyploid agamic complexes. We developed microsatellite markers from A.
Ramhari Thapa, Randall J. Bayer, Jennifer R. Mandel   +2 more
doaj   +1 more source

Stronger selection can slow down evolution driven by recombination on a smooth fitness landscape. [PDF]

PLoS ONE, 2017
Stronger selection implies faster evolution-that is, the greater the force, the faster the change. This apparently self-evident proposition, however, is derived under the assumption that genetic variation within a population is primarily supplied by ...
Masahiko Ueda, Nobuto Takeuchi, Kunihiko Kaneko   +2 more
doaj   +1 more source

Genetic structure and diversity of Calycolpus moritzianus (Myrtaceae) in the north-eastern Andes of Colombia

Revista Mexicana de Biodiversidad, 2021
The Arrayán tree (Calycolpus moritzianus) is an endemic species from northern South America and it is important for its potential in the medical and cosmetic industry.
Diego Alexander Hernández-Contreras, Franklin de Jesús Torres-Torres, Mauricio Figueroa-Lozano, Luis Roberto Sánchez-Montaño, Andrés Mauricio Posso-Terranova, Jaime Eduardo Muñoz-Flórez   +5 more
doaj   +1 more source

Rate of Fixation of Rare Variants in a Population

bioRxiv, 2017
The process of molecular evolution has been dominated by the Kimura paradigm for nearly 60 years; mutations arise at a certain rate in the population and they go to fixation with a probability given by Kimura’s classic formula, which assumes there are no
Bhavin S. Khatri
semanticscholar   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Epigenetics and Evolution: Transposons and the Stochastic Epigenetic Modification Model

AIMS Genetics, 2015
In addition to genetic variation, epigenetic variation and transposons can greatly affect the evolutionary fitnesses landscape and gene expression. Previously we proposed a mathematical treatment of a general epigenetic variation model that we called ...
Sergio Branciamore, Andrei S. Rodin, Grigoriy Gogoshin, Arthur D. Riggs   +3 more
doaj   +1 more source

An allozyme polymorphism is associated with a large chromosomal inversion in the marine snail Littorina fabalis

Evolutionary Applications, 2023
Understanding the genetic targets of natural selection is one of the most challenging goals of population genetics. Some of the earliest candidate genes were identified from associations between allozyme allele frequencies and environmental variation ...
Alan Le Moan, Marina Panova, Aurélien De Jode, Olga Ortega‐Martinez, Mårten Duvetorp, Rui Faria, Roger Butlin, Kerstin Johannesson   +7 more
doaj   +1 more source