Results 71 to 80 of about 143,746 (232)

An allozyme polymorphism is associated with a large chromosomal inversion in the marine snail Littorina fabalis

Evolutionary Applications, 2023
Understanding the genetic targets of natural selection is one of the most challenging goals of population genetics. Some of the earliest candidate genes were identified from associations between allozyme allele frequencies and environmental variation ...
Alan Le Moan, Marina Panova, Aurélien De Jode, Olga Ortega‐Martinez, Mårten Duvetorp, Rui Faria, Roger Butlin, Kerstin Johannesson   +7 more
doaj   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Fisher-Wright model with deterministic seed bank and selection

, 2016
Seed banks are a common characteristics to many plant species, which allow storage of genetic diversity in the soil as dormant seeds for various periods of time.
Koopmann, Bendix, Müller, Johannes, Tellier, Aurélien, Živković, Daniel   +3 more
core   +1 more source

Tradeoff between short-term and long-term adaptation in a changing environment [PDF]

, 2005
We investigate the competition dynamics of two microbial or viral strains that live in an environment that switches periodically between two states. One of the strains is adapted to the long-term environment, but pays a short-term cost, while the other ...
C. O. Wilke, C. O. Wilke, C. O. Wilke, Claus O. Wilke, E. Domingo, I. S. Novella, J. F. Crow, L. A. Cooper, M. Eigen, M. Kimura, P. E. Turner, Robert Forster, S. C. Weaver   +12 more
core   +2 more sources

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Population dynamics in compressible flows

, 2012
Organisms often grow, migrate and compete in liquid environments, as well as on solid surfaces. However, relatively little is known about what happens when competing species are mixed and compressed by fluid turbulence.
A. Kolmogorov, A. Kolmogorov, A. Kurganov, A. Martin, A.P. Martin, A.R. Robinson, A.R. Robinson, C. Torney, D. R. Nelson, D.R. Nelson, F. D’Ovidio, F. Peters, F. Toschi, F. Toschi, G. Boffetta, G. Boffetta, G. Falkovich, I.M. Held, J. Bec, J. Bec, J. Bec, J. ichi Wakita, J. Mannik, J.R. Cressman, K. Korolev, K. Mizobota, K.A. Dahmen, L. Biferale, L. Thomas, M. H. Jensen, M. Kimura, N.M. Shnerb, O. Hallatschek, O. Hallatschek, O. Hallatschek, P. Klein, P. Klein, P. Perlekar, P. Perlekar, R. Benzi, R. Benzi, R. Benzi, R. Fisher, S. Berti, S. Pigolotti, T. Neicu, T. Tel, W. McKiver, W. Saarloos van, W.J. McKiver, W.M. Durham, X. Capet   +51 more
core   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Protein evolution depends on multiple distinct population size parameters

BMC Evolutionary Biology, 2018
That population size affects the fate of new mutations arising in genomes, modulating both how frequently they arise and how efficiently natural selection is able to filter them, is well established.
Alexander Platt, Claudia C. Weber, David A. Liberles   +2 more
doaj   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Comparing newly developed SNP barcode panels with microsatellites to explore population genetics of malaria parasites in the Peruvian Amazon

Frontiers in Genetics
IntroductionMalaria molecular surveillance (MMS) can provide insights into transmission dynamics, guiding national control programs. We previously designed AmpliSeq assays for MMS, which include different traits of interest (resistance markers and pfhrp2/
Luis Cabrera-Sosa, Luis Cabrera-Sosa, Luis Cabrera-Sosa, Mahdi Safarpour, Johanna Helena Kattenberg, Roberson Ramirez, Joseph M. Vinetz, Joseph M. Vinetz, Joseph M. Vinetz, Anna Rosanas-Urgell, Dionicia Gamboa, Dionicia Gamboa, Dionicia Gamboa, Dionicia Gamboa, Christopher Delgado-Ratto, Christopher Delgado-Ratto   +15 more
doaj   +1 more source