Results 71 to 80 of about 147,226 (247)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Protein evolution depends on multiple distinct population size parameters

BMC Evolutionary Biology, 2018
That population size affects the fate of new mutations arising in genomes, modulating both how frequently they arise and how efficiently natural selection is able to filter them, is well established.
Alexander Platt, Claudia C. Weber, David A. Liberles   +2 more
doaj   +1 more source

Fixation and consensus times on a network: a unified approach

, 2008
We investigate a set of stochastic models of biodiversity, population genetics, language evolution and opinion dynamics on a network within a common framework. Each node has a state, 0 < x_i < 1, with interactions specified by strengths m_{ij}.
A. J. McKane, C. W. Gardiner, E. Gordon, G. J. Baxter, J. Wakeley, J. F. Crow, P. Erdös, P. Trudgill, R. A. Blythe, S. P. Hubbell   +9 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Comparing newly developed SNP barcode panels with microsatellites to explore population genetics of malaria parasites in the Peruvian Amazon

Frontiers in Genetics
IntroductionMalaria molecular surveillance (MMS) can provide insights into transmission dynamics, guiding national control programs. We previously designed AmpliSeq assays for MMS, which include different traits of interest (resistance markers and pfhrp2/
Luis Cabrera-Sosa, Luis Cabrera-Sosa, Luis Cabrera-Sosa, Mahdi Safarpour, Johanna Helena Kattenberg, Roberson Ramirez, Joseph M. Vinetz, Joseph M. Vinetz, Joseph M. Vinetz, Anna Rosanas-Urgell, Dionicia Gamboa, Dionicia Gamboa, Dionicia Gamboa, Dionicia Gamboa, Christopher Delgado-Ratto, Christopher Delgado-Ratto   +15 more
doaj   +1 more source

Intrinsic adaptive value and early fate of gene duplication revealed by a bottom-up approach

eLife, 2018
The population genetic mechanisms governing the preservation of gene duplicates, especially in the critical very initial phase, have remained largely unknown.
Guillermo Rodrigo, Mario A Fares
doaj   +1 more source

No Population Genetic Structure of Skipjack Tuna (Katsuwonus pelamis) in the Tropical Western and Central Pacific Assessed Using Single Nucleotide Polymorphisms

Frontiers in Marine Science, 2020
Skipjack tuna (Katsuwonus pelamis) has historically been considered panmictic at the ocean basin scale because of the species’ life history and substantial absolute population size.
Giulia Anderson, Giulia Anderson, Monal Lal, Monal Lal, Brian Stockwell, John Hampton, Neville Smith, Simon Nicol, Ciro Rico, Ciro Rico   +9 more
doaj   +1 more source

Fixation probabilities for any configuration of two strategies on regular graphs

, 2016
Population structure and spatial heterogeneity are integral components of evolutionary dynamics, in general, and of evolution of cooperation, in particular. Structure can promote the emergence of cooperation in some populations and suppress it in others.
Chen, Yu-Ting, McAvoy, Alex, Nowak, Martin A.   +2 more
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Drosophila yakuba mayottensis, a new model for the study of incipient ecological speciation

Fly, 2017
A full understanding of how ecological factors drive the fixation of genetic changes during speciation is obscured by the lack of appropriate models with clear natural history and powerful genetic toolkits.
Amir Yassin
doaj   +1 more source