Results 91 to 100 of about 150,410 (356)

Fixing the internet [PDF]

open access: yesScience, 2018
Data breaches at Facebook and Google—and along with Amazon, those firms' online dominance—crest a growing wave of anxiety around the internet's evolving structure and its impact on humanity. Three keys to the decades-long global expansion of the internet and the World Wide Web are breaking down.
openaire   +3 more sources

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

open access: yesAdvanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng   +14 more
wiley   +1 more source

The valvula cerebelli of the spiny eel, Macrognathus aculeatus, receives primary lateral-line afferents from the rostrum of the upper jaw [PDF]

open access: yes, 1991
In the spiny eel, Macrognathus aculeatus, anterodorsal and (to a lesser degree) anteroventral lateralline nerves project massively to the granular layer of the valvula cerebelli, throughout its rostrocaudal extent.
Hofmann, M. H.   +2 more
core   +1 more source

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

open access: yesAdvanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao   +12 more
wiley   +1 more source

Microanalytical identification of barium sulphate crystals in statoliths of Chara Rhizoids [PDF]

open access: yes
In contrast to higher plants, Chara rhizoids contain statolith vacuoles filled with biocrystallites of BaS04 in the form of rods composed of globular subunits ca. 7 nm in diameter. The revelation of the crystallites under electron microscopy is dependent
Lauchli, A.   +2 more
core   +1 more source

To the knowledge of the genus Pseudospora Cienkowski [Translation from: Archiv fur Protistenkunde 59, 350-368, 1927] [PDF]

open access: yes, 1981
Morphological observations on the two types of Pseudospora are given. The two Pseudospora whic are described are Pseudospora eudorini and Pseudospora volvocis.
Roskin, G.
core  

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

open access: yesAdvanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao   +7 more
wiley   +1 more source

Quantifying the effectiveness of fixative coatings in reducing airborne release fractions under impact stress

open access: yesNuclear Engineering and Technology
The decontamination and decommissioning (D&D) of nuclear facilities present significant challenges due to residual radioactive contamination, which threatens workers, the public, and the environment. Accurate airborne release fractions (ARFs) estimations
Mellissa Komninakis   +4 more
doaj   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

open access: yesAdvanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li   +13 more
wiley   +1 more source

Optimized fixation of actin filaments for improved indirect immunofluorescence staining of rickettsiae

open access: yesBMC Research Notes, 2019
Objective The objective was to investigate fixative solutions: 3.7% formaldehyde, 4% paraformaldehyde, 4% paraformaldehyde in the cytoskeletal buffer and 4% paraformaldehyde in PHEM buffer (containing PIPES, HEPES, EGTA and MgCl2), applicable for ...
Monika Danchenko   +3 more
doaj   +1 more source

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