Results 101 to 110 of about 102,036 (290)
Science, 2018 Data breaches at Facebook and Google—and along with Amazon, those firms' online dominance—crest a growing wave of anxiety around the internet's evolving structure and its impact on humanity. Three keys to the decades-long global expansion of the internet and the World Wide Web are breaking down.
openaire +4 more sources
A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau
Advanced Science, EarlyView.TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun +12 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song +9 more
wiley +1 more source
The effect of formaldehyde solution in pitfall traps on the probability of catching woodlice (Isopoda, Oniscidea) [PDF]
ZooKeysPitfall traps containing a fixative solution are commonly used by ecologists to study ground-dwelling invertebrates. The effect of the solution on the animals being caught is a frequent topic of studies.
Ivan Hadrián Tuf +2 more
doaj +3 more sources
Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery
Advanced Science, EarlyView.A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li +9 more
wiley +1 more source
Linchuang shenzangbing zazhi, 2015 Objective The mice were infused with different schemes and kidney cell glycocalyxes were observed with transmission electron microscope.The aim was to find the best lanthanum tracing method of displaying kidney cell glycocalyxes.Methods C57/BL6 mice were
LIU Zeng-bo +4 more
doaj
PLoS ONE, 2017 Tissue fixation in phosphate buffered formalin (PBF) remains the standard procedure in histopathology, since it results in an optimal structural, antigenic and molecular preservation that justifies the pivotal role presently played by diagnoses on PBF ...
Gianni Bussolati +9 more
doaj +1 more source
BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells
Advanced Science, EarlyView.BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Xin Li +8 more
wiley +1 more source
MRIMS Journal of Health SciencesBackground: Formal saline is an extensively used cheapest and easily available tissue fixative. However, formalin has been proven to have carcinogenic effects.
Lakshya Venugopal, Vasudha Kulkarni
doaj +1 more source
Advanced Science, EarlyView.A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li +9 more
wiley +1 more source