Results 61 to 70 of about 102,036 (290)

Fixative preparation for recycling of personal computer mainboards

, 2009
Tato bakalářská práce se zabývá konstrukčním řešením upínacího přípravku, pro odřezání elektronických součástek z povrchu PC desek. Upínací část přípravku je tvo-řena čtyřmi čepy, na které bude deska plošného spoje nasazena a následně napnuta.
Kostka, Radek
core   +2 more sources

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

To Fix or Not to Fix, the Fix: Reassessing the Effectiveness of the 4pm Fix. A Pre-Registered Study

Pacific-Basin Finance Journal
This study critically re-evaluates the effectiveness of the WM/Refinitiv (WMR) methodology for Foreign Exchange (FX) benchmark rates following its revision in 2015. Through the use of proprietary high-frequency trading data provided by Refinitiv, the research assesses the representativeness, attainability, and robustness of the WMR 4 pm fix.
Benenchia, Matteo, Galati, Luca, Lepone, Andrew   +2 more
openaire   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Polyvinyl Alcohol-Fixative-Adhesive for Small Helminths and Protozoa [PDF]

, 1954
Following the method of Brooke and Goldman (1949), the author was able to fix, mount and stain small helminths and parasitic protozoa of fish in polyvinyl alcohol-fixative smears. However, because there was much granular material in the PVA-Schaudin\u27s
Hoffman, Glenn L.
core  

Comparison of Oral Microbiota Collected Using Multiple Methods and Recommendations for New Epidemiologic Studies

mSystems, 2020
Epidemiologic studies use various biosample collection methods to study associations between human oral microbiota and health outcomes. However, the agreement between the different methods is unclear.
Yukiko Yano, Xing Hua, Yunhu Wan, Shalabh Suman, Bin Zhu, Casey L. Dagnall, Amy Hutchinson, Kristine Jones, Belynda D. Hicks, Jianxin Shi, Christian C. Abnet, Emily Vogtmann   +11 more
doaj   +1 more source

Comparison of histomorphology and DNA preservation produced by fixatives in the veterinary diagnostic laboratory setting [PDF]

PeerJ, 2014
Histopathology is the most useful tool for diagnosis of a number of diseases, especially cancer. To be effective, histopathology requires that tissues be fixed prior to processing.
William F. Craft, Julia A. Conway, Michael J. Dark   +2 more
doaj   +2 more sources

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Effects of fixative and buffer on morphology and ultrastructure of a freshwater planctomycete, Gemmata obscuriglobus

, 1995
The effects of different combinations of fixative and buffer on preservation of shape and structure of cells of the freshwater planctomycete bacterium Gemmata obscuriglobus were examined using light and electron microscopy.
H.M. Hosmer, J.A. Fuerst, Lindsay, M. R., Fuerst, J. A., M.R. Lindsay, Hosmer, H. M., Webb, R. I., R.I. Webb   +7 more
core   +1 more source