Results 51 to 60 of about 95,582 (265)
mSystems, 2020 Epidemiologic studies use various biosample collection methods to study associations between human oral microbiota and health outcomes. However, the agreement between the different methods is unclear.
Yukiko Yano +11 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin +16 more
wiley +1 more source
Comparison of histomorphology and DNA preservation produced by fixatives in the veterinary diagnostic laboratory setting [PDF]
PeerJ, 2014 Histopathology is the most useful tool for diagnosis of a number of diseases, especially cancer. To be effective, histopathology requires that tissues be fixed prior to processing.
William F. Craft +2 more
doaj +2 more sources
Advanced Science, EarlyView.Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters +12 more
wiley +1 more source
Mix it and fix it: functions of composite olfactory signals in ring-tailed lemurs [PDF]
Royal Society Open Science, 2016 Animals communicating via scent often deposit composite signals that incorporate odorants from multiple sources; however, the function of mixing chemical signals remains understudied.
Lydia K. Greene +5 more
doaj +1 more source
Advanced Science, EarlyView.SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng +18 more
wiley +1 more source
Fixed points and homotopy fixed points
Commentarii Mathematici Helvetici, 1988 Let G be a finite group, EG be a free contractible G-space, and define \(X^{hG}=Map_ G(EG,X)\) (equivariant mapping space). The main theorem of this paper proves that the following two statements are equivalent (Theorem A): (1) G is a p-group. (2) For every finite G-simplicial complex X, the fixed point set \(X^ G=\emptyset\) if and only if \(X^{hG ...
Zabrodsky, A., Dror Farjoun, E.
openaire +1 more source
Advanced Science, EarlyView.HLP‐SeNPs, a Lysimachia christinae polysaccharide‐modified selenium nanoparticle, treat kidney stones by downregulating TOMM22 expression, which reduces PINK1 translocation into mitochondria and promotes its retention on the outer mitochondrial membrane.
Junyi Yang +10 more
wiley +1 more source
On Characterizations of Fixed and Common Fixed Points
Journal of Mathematical Analysis and Applications, 1998 The authors introduce the concept of \(L\)-mapping which is equivalent to the concept of \(C\)-mapping introduced by \textit{S. Zhang} [Proc. Am. Math. Soc. 97, 343-346 (1986; Zbl 0593.54045)] and establish criteria for the existence of fixed points of \(L\)-mappings.
Liu, Zeqing, Xu, Yuguang, Cho, Yeol Je
openaire +2 more sources
Renal IGFBP6 Interacts With THBS1 to Drive Renal Cellular Senescence and Fibrosis
Advanced Science, EarlyView.ABSTRACT Epithelial dedifferentiation and myofibroblast activation are critical drivers of chronic kidney disease (CKD) progression. Elevated levels of IGFBP6 have been linked to decreased renal function in CKD patients, but its precise role and underlying mechanisms remain unclear.
Ju‐tao Yu +26 more
wiley +1 more source