Results 281 to 290 of about 452,734 (338)

Fixed-Dose Combination Therapy in Hypertension

High Blood Pressure & Cardiovascular Prevention, 2012
The goal of antihypertensive therapy is to reduce the risk associated with blood pressure elevation. Although the choice of first-line drug therapy may exert some effects on different long-term cardiovascular endpoints, randomized clinical trials and meta-analyses demonstrated that blood pressure reduction per se is the primary determinant in primary ...
ANGELI, FABIO, REBOLDI, Gianpaolo, G. Mazzotta, M. Garofoli, E. Ramundo, C. Poltronieri, P. Verdecchia   +6 more
openaire   +5 more sources

Fixed-dose combination of pertuzumab and trastuzumab for subcutaneous injection plus chemotherapy in HER2-positive early breast cancer (FeDeriCa): a randomised, open-label, multicentre, non-inferiority, phase 3 study.

The Lancet Oncology, 2020
BACKGROUND A subcutaneous formulation of pertuzumab and trastuzumab with recombinant human hyaluronidase in one ready-to-use, fixed-dose combination vial (pertuzumab, trastuzumab, and hyaluronidase-zzxf) was approved by the US Food and Drug ...
A. Tan, S. Im, A. Mattar, R. Colomer, D. Stroyakovskii, Z. Nowecki, M. De Laurentiis, J. Pierga, K. Jung, C. Schem, Alexandra S. Hogea, T. Badovinac Crnjevic, S. Heeson, M. Shivhare, Whitney P. Kirschbrown, E. Restuccia, C. Jackisch   +16 more
semanticscholar   +1 more source

A fixed dose combination of ibuprofen and famotidine

Expert Opinion on Investigational Drugs, 2009
The NSAID class of medications is frequently used for mild to moderate pain. While overall safe, NSAIDs have several important adverse effects including esophageal, gastric and duodenal ulceration which limit their use. This has led to the development of NSAIDs with either less gastrointestinal side effects or concurrent use of medications to prevent ...
John W, Birk, Matthew, Myers
openaire   +2 more sources

Fixed-dose combination of rosuvastatin and ezetimibe: treating hypercholesteremia according to cardiovascular risk

Expert Review of Clinical Pharmacology, 2021
Introduction: Reducing low-density lipoprotein cholesterol (LDL-C) with lipid-lowering therapies has been associated with a decrease in the frequency of cardiovascular events.
V. Barrios, C. Escobar
semanticscholar   +1 more source

Fixed-Dose Combination Inhalers

2016
In asthma and chronic obstructive pulmonary disease (COPD), an important step in simplifying management and improving adherence with prescribed therapy is to reduce the dose frequency to the minimum necessary to maintain disease control. Fixed-dose combination (FDC) therapy might enhance compliance by decreasing the number of medications and/or the ...
Cazzola, Mario, MATERA, Maria Gabriella
openaire   +2 more sources

Compliance and fixed-dose combination therapy

Current Hypertension Reports, 2007
Despite data on the importance of blood pressure control in preventing cardiovascular and cerebrovascular events, only 34% of hypertensive patients have their blood pressure under control. The National Council on Patient Information and Education has estimated that the compliance rate is just over 30% for chronic conditions like hypertension ...
Sripal, Bangalore, Anupama, Shahane, Sanobar, Parkar, Franz H, Messerli   +3 more
openaire   +2 more sources

Fixed-dose combination therapy for the prevention of atherosclerotic cardiovascular disease

Nature Medicine
Fixed-dose combination (FDC) therapy, also known as polypill therapy, targets risk factors for atherosclerotic cardiovascular disease (ASCVD) and has been proposed as a strategy to reduce global ASCVD burden.
Anubha Agarwal, Priya M Mehta, Tyler A. Jacobson, N. Shah, Jiancheng Ye, JingJing Z. Zhu, Q. Wafford, E. Bahiru, A. D. de Cates, Shah Ebrahim, Dorairaj Prabhakaran, Anthony Rodgers, Mark D. Huffman   +12 more
semanticscholar   +1 more source

Curcumin-Based Fixed Dose Combination Products for Cholesterol Management: A Narrative Review.

ACS Pharmacology & Translational Science
Curcumin, a polyphenol compound that belongs to a class of molecules known as curcuminoids, may interact with various biological macromolecules in the body, including proteins, nucleic acids, and lipids.
A. Boretti
semanticscholar   +1 more source

Telmisartan/hydrochlorothiazide: a new fixed dose combination

Expert Review of Cardiovascular Therapy, 2005
Many patients with hypertension require two or more antihypertensive drugs with complementary mechanisms of action to lower their blood pressure and attain the therapeutic goals specified in internationally accepted guidelines. Yet, these latter guidelines offer the choice of fixed dose combinations as possible first-step therapies.
Marc Maillard, Michel Burnier
exaly   +4 more sources

Fixed dose combinations of cardiovascular drugs

BMJ, 2014
One of the most feasible ways to improve adherence Drug treatment for cardiovascular disease remains inadequate globally,1 and many adults with cardiovascular disease or a high risk of cardiovascular disease receive no drug treatment. In response, the World Health Organization and its member states have agreed on a target to treat 50% of eligible ...
openaire   +2 more sources