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Fixed-Dose Combination Therapy for Psoriasis
American Journal of Clinical Dermatology, 2004Fixed-dose combination therapy offers stable products containing two or more medications with different mechanisms of action and safety profiles. It is also convenient for patients since only one product rather than two or more needs to be applied. Topical corticosteroids are often the mainstay of therapy in psoriasis.
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Fixed‐dose single tablet antidiabetic combinations
Diabetes, Obesity and Metabolism, 2009Combinations of two or more oral agents with different mechanisms of action are often used for the management of hyperglycaemia in type 2 diabetes. While these combinations have customarily been taken as separate tablets, several fixed‐dose single tablet combinations are now available. These are based on bioequivalence with the separate tablets, giving
C J, Bailey, C, Day
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Aggrenox: A Fixed-Dose Combination of Aspirin and Dipyridamole
The Annals of Pharmacotherapy, 2000OBJECTIVE: To describe the pharmacology, pharmacokinetics, efficacy, and safety of a fixed-dose combination of aspirin and extended-release (ER) dipyridamole indicated for the secondary prevention of stroke. DATA SOURCES: Published ...
T L, Lenz, D E, Hilleman
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Acetylsalicylic Acid/Esomeprazole Fixed-Dose Combination
Drugs & Aging, 2012The fixed-dose acetylsalicylic acid (ASA)/esomeprazole capsule combines the cardiovascular (CV) protective effects of low-dose ASA with the gastroprotective effects of the proton pump inhibitor esomeprazole. It is approved for use as a convenient once-daily regimen in the prevention of CV and cerebrovascular events in patients requiring continuous low ...
Celeste B, Burness, Lesley J, Scott
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Translational medicine @ UniSa, 2017
The introduction of fixed combination of ACEi+CCB (Fixed) has significantly increased patients compliance and adherence to therapy. At the moment, however, there are no data suggesting the better control of once-daily fixed (Fixed) over free doses in ...
V. Visco +7 more
semanticscholar +1 more source
The introduction of fixed combination of ACEi+CCB (Fixed) has significantly increased patients compliance and adherence to therapy. At the moment, however, there are no data suggesting the better control of once-daily fixed (Fixed) over free doses in ...
V. Visco +7 more
semanticscholar +1 more source
2019
Fixed-dose combinations or FDCs are combinations of two or more active pharmaceutical ingredients in a single dosage form in a fixed ratio usually for the same indication. FDCs aim to improve the therapeutic efficacy of each component of the medication while reducing the adverse drug reactions.
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Fixed-dose combinations or FDCs are combinations of two or more active pharmaceutical ingredients in a single dosage form in a fixed ratio usually for the same indication. FDCs aim to improve the therapeutic efficacy of each component of the medication while reducing the adverse drug reactions.
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The Lancet Haematology, 2019
BACKGROUND Decitabine, a DNA methyltransferase 1 inhibitor or DNA hypomethylating compound, is not readily orally bioavailable because of rapid clearance by cytidine deaminase (CDA) in the gut and liver.
M. Savona +12 more
semanticscholar +1 more source
BACKGROUND Decitabine, a DNA methyltransferase 1 inhibitor or DNA hypomethylating compound, is not readily orally bioavailable because of rapid clearance by cytidine deaminase (CDA) in the gut and liver.
M. Savona +12 more
semanticscholar +1 more source
Fixed-dose combinations for emerging treatment of pain
Expert Opinion on Pharmacotherapy, 2012Pain is a large and growing medical need that is not currently being fully met, primarily due to the shortcomings of existing analgesics (insufficient efficacy or limiting side-effects). Better outcomes might be achieved using a combination of analgesics.
Robert B, Raffa +3 more
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Diabetes, obesity and metabolism, 2019
To assess the pharmacokinetic (PK) and pharmacodynamic characteristics of VI‐0521, a fixed‐dose combination of immediate‐release phentermine (PHEN) and extended‐release topiramate (TPM) in adolescents aged 12 to 17 years with obesity, and to report ...
D. Hsia +7 more
semanticscholar +1 more source
To assess the pharmacokinetic (PK) and pharmacodynamic characteristics of VI‐0521, a fixed‐dose combination of immediate‐release phentermine (PHEN) and extended‐release topiramate (TPM) in adolescents aged 12 to 17 years with obesity, and to report ...
D. Hsia +7 more
semanticscholar +1 more source
Journal of Molecular Liquids, 2019
In this study, we designed a fixed-dose combination (FDC) for Darunavir (DRV) and Ritonavir (RTV) using molecular simulations as a tool. Molecular modeling allowed us to choose the solvent and antisolvent required for the formation of nanosuspension by ...
C. Mehta +8 more
semanticscholar +1 more source
In this study, we designed a fixed-dose combination (FDC) for Darunavir (DRV) and Ritonavir (RTV) using molecular simulations as a tool. Molecular modeling allowed us to choose the solvent and antisolvent required for the formation of nanosuspension by ...
C. Mehta +8 more
semanticscholar +1 more source