Results 91 to 100 of about 5,976,148 (331)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Demonstratio Mathematica, 2016 The purpose of this paper is to study convergence of a newly defined modified S-iteration process to a common fixed point of two asymptotically quasi-nonexpansive type mappings in the setting of CAT(0) space. We give a suffcient condition for convergence
Saluja G. S.
doaj +1 more source
Some fixed point theorems for discontinuous mappings [PDF]
This paper provides a fixed point theorem à la Schauder, where the mappings considered are possibly discontinuous. Our main result generalizes and unifies several well-known results.Schauder fixed point theorem, Brouwer fixed point theorem, discontinuity.
Philippe Bich
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Three-Step Fixed Point Iteration for Generalized Multivalued Mapping in Banach Spaces
Journal of Applied Mathematics, 2012 The convergence of three-step fixed point iterative processes for generalized multivalued nonexpansive mapping was considered in this paper. Under some different conditions, the sequences of three-step fixed point iterates strongly or weakly converge to ...
Zhanfei Zuo
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hybrid Inertial Self-Adaptive Iterative Methods for Split Variational Inclusion Problems
AxiomsHerein, we present two hybrid inertial self-adaptive iterative methods for determining the combined solution of the split variational inclusions and fixed-point problems.
Doaa Filali +3 more
doaj +1 more source
Distributed Fixed Point Methods with Compressed Iterates
CoRR, 2019 We propose basic and natural assumptions under which iterative optimization methods with compressed iterates can be analyzed. This problem is motivated by the practice of federated learning, where a large model stored in the cloud is compressed before it is sent to a mobile device, which then proceeds with training based on local data.
Sélim Chraibi +5 more
openaire +3 more sources