Results 81 to 90 of about 57,211 (263)

Fixed point results for generalized convex orbital Lipschitz operators

open access: yesDemonstratio Mathematica
Krasnoselskii’s iteration is a classical and important method for approximating the fixed point of an operator that satisfies certain conditions. Many authors have used this approach to obtain several famous fixed point theorems for different types of ...
Zhou Mi   +4 more
doaj   +1 more source

Strong Convergence Theorems for a Countable Family of Nonexpansive Mappings in Convex Metric Spaces

open access: yesAbstract and Applied Analysis, 2011
We introduce a new modified Halpern iteration for a countable infinite family of nonexpansive mappings {Tn} in convex metric spaces. We prove that the sequence {xn} generated by the proposed iteration is an approximating fixed point sequence of a ...
Withun Phuengrattana, Suthep Suantai
doaj   +1 more source

Stabilization effect of fission source in coupled Monte Carlo simulations

open access: yesNuclear Engineering and Technology, 2017
A fission source can act as a stabilization element in coupled Monte Carlo simulations. We have observed this while studying numerical instabilities in nonlinear steady-state simulations performed by a Monte Carlo criticality solver that is coupled to a ...
Börge Olsen, Jan Dufek
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

The convergence of the Euler's method

open access: yesJournal of Numerical Analysis and Approximation Theory, 2010
In this article we study the Euler's iterative method. For this method we give a global theorem of convergence. In the last section of the paper we give a numerical example which illustrates the result exposed in this work.
Raluca Anamaria Sălăjan (Pomian)
doaj   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

An Efficient Semi-Analytical Solution of a One-Dimensional Curvature Equation that Describes the Human Corneal Shape

open access: yesMathematical and Computational Applications, 2019
In this paper, a numerical approach is proposed to find a semi analytical solution for a prescribed anisotropic mean curvature equation modeling the human corneal shape.
Marwan Abukhaled, Suheil Khuri
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

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