Results 91 to 100 of about 380,543 (330)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Fixed point iteration for pseudocontractive maps.

, 1999
Let T be a continuous pseudocontractive self-map of a compact convex subset K of a Hilbert space H. It is proved that the Ishikawa iteration process converges strongly to a fixed point of T.
Chika Moore, C E Chidume
core  

Hybrid Inertial Self-Adaptive Iterative Methods for Split Variational Inclusion Problems

Axioms
Herein, we present two hybrid inertial self-adaptive iterative methods for determining the combined solution of the split variational inclusions and fixed-point problems.
Doaa Filali, Mohammad Dilshad, Atiaf Farhan Yahya Alfaifi, Mohammad Akram   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Complete Axioms for Categorical Fixed-point Operators [PDF]

, 2000
We give an axiomatic treatment of fixed-point operators in categories. A notion of iteration operator is defined, embodying the equational properties of iteration theories. We prove a general completeness theorem for iteration operators, relying on a new,
Gordon Plotkin, Simpson, Alex, G. Plotkin, Alex Simpson, A. Simpson, Plotkin, Gordon   +5 more
core   +1 more source

Fixed point iteration processes for asymptotic pointwise nonexpansive mapping in modular function spaces

, 2012
Let Lρ be a uniformly convex modular function space with a strong Opial property. Let T:C→C be an asymptotic pointwise nonexpansive mapping, where C is a ρ-a.e. compact convex subset of Lρ.
B. B. Dehaish, W. Kozlowski
semanticscholar   +1 more source

Three-Step Fixed Point Iteration for Generalized Multivalued Mapping in Banach Spaces

Journal of Applied Mathematics, 2012
The convergence of three-step fixed point iterative processes for generalized multivalued nonexpansive mapping was considered in this paper. Under some different conditions, the sequences of three-step fixed point iterates strongly or weakly converge to ...
Zhanfei Zuo
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Iteration of fixed point on hyperspaces

, 2010
L et X be a compact, convex subset of a Banach space E and CC (X ) be the co l2 lection of all non2emp ty compact, coonvex subset of X equipped w ith the H ausdo rff m etric h.
Hu, Thakyin; Huang, Jui-chi
core