Results 101 to 110 of about 380,543 (330)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Strong Convergence Theorems for a Countable Family of Nonexpansive Mappings in Convex Metric Spaces

open access: yesAbstract and Applied Analysis, 2011
We introduce a new modified Halpern iteration for a countable infinite family of nonexpansive mappings {Tn} in convex metric spaces. We prove that the sequence {xn} generated by the proposed iteration is an approximating fixed point sequence of a ...
Withun Phuengrattana, Suthep Suantai
doaj   +1 more source

Strongly Convergence of Two Iterations For a Common Fixed Point with an Application

open access: yesIbn Al-Haitham Journal for Pure and Applied Sciences, 2019
     In this paper, we study some cases of a common fixed point theorem for classes of firmly nonexpansive and generalized nonexpansive maps. In addition, we establish that the Picard-Mann iteration is faster than Noor iteration and we used Noor ...
Zahra Mahmood Mohamed Hasan   +1 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Fixed point results for generalized convex orbital Lipschitz operators

open access: yesDemonstratio Mathematica
Krasnoselskii’s iteration is a classical and important method for approximating the fixed point of an operator that satisfies certain conditions. Many authors have used this approach to obtain several famous fixed point theorems for different types of ...
Zhou Mi   +4 more
doaj   +1 more source

Stabilization effect of fission source in coupled Monte Carlo simulations

open access: yesNuclear Engineering and Technology, 2017
A fission source can act as a stabilization element in coupled Monte Carlo simulations. We have observed this while studying numerical instabilities in nonlinear steady-state simulations performed by a Monte Carlo criticality solver that is coupled to a ...
Börge Olsen, Jan Dufek
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

The convergence of the Euler's method

open access: yesJournal of Numerical Analysis and Approximation Theory, 2010
In this article we study the Euler's iterative method. For this method we give a global theorem of convergence. In the last section of the paper we give a numerical example which illustrates the result exposed in this work.
Raluca Anamaria Sălăjan (Pomian)
doaj   +2 more sources

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