Results 131 to 140 of about 1,170,010 (258)

From Moral Fixed Points to Epistemic Fixed Points

, 2018
In a recent paper Terence Cuneo and Russ Shafer-Landau argue that there are moral conceptual truths that are substantive in content, what they called “moral fixed points.” I argue that insofar as we have some reason to postulate moral fixed points, we have equal reason to postulate epistemic fixed points (e.g. the factivity condition).
openaire   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Results on fixed points in b-metric space by altering distance functions. [PDF]

Heliyon
Seshagiri Rao N, Aloqaily A, Mlaiki N.
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Evidence for complex fixed points in pandemic data

, 2020
Cacciapaglia G, Sannino F.
europepmc   +2 more sources

Exploring strong controlled partial metric type spaces: Analysis of fixed points and theoretical contributions. [PDF]

Heliyon
Santina D, Mior Othman WA, Wong KB, Mlaiki N.   +3 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A Study on Miniaturized In-Situ Self-Calibrated Thermometers Based on Ga and Ga-Zn Fixed Points. [PDF]

Sensors (Basel)
Huang H, Cai W, Mao Y, Wan K, Wen Y, Han Y, Zhang Q, Zhang R, Zheng X.   +8 more
europepmc   +1 more source

Coarse Graining, Fixed Points, and Scaling in a Large Population of Neurons. [PDF]

Phys Rev Lett, 2019
Meshulam L, Gauthier JL, Brody CD, Tank DW, Bialek W.   +4 more
europepmc   +1 more source