Results 91 to 100 of about 425,800 (302)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Optimization Control Strategy for Light Load Efficiency of Four-Switch Buck-Boost Converter

World Electric Vehicle Journal
The four-switch buck-boost (FSBB) converter usually adopts a pseudo-continuous conduction mode (PCCM) soft switching (ZVS) control strategy, but there is a problem with the low efficiency of FSBB converters under light loads.
Siyuan Gao, Fanghua Zhang, Hongxin Mei
doaj   +1 more source

Shuttle-promoted nano-mechanical current switch [PDF]

, 2015
We investigate electron shuttling in three-terminal nanoelectromechanocal device built on a movable metallic rod oscillating between two drains. The device shows a double-well shaped electromechanical potential tunable by a source-drain bias voltage ...
Gorelik, Leonid Y., Kikoin, Konstantin, Kiselev, Mikhail N., Shekhter, Robert I., Song, Taegeun   +4 more
core   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A FCS-MPC for Low-Switching-Frequency Grid-Tied CHB Inverters Complying With EN50160 and IEEE Std 1547-2018 Standards

IEEE Open Journal of Power Electronics
This paper presents a novel multi-objective finite-control-set model predictive control strategy for LCL-filtered grid-connected three-phase five-level cascaded H-bridge multilevel inverters operating at low-switching frequency.
Gioacchino Scaglione, Giuseppe Sorrentino, Claudio Nevoloso, Giuseppe Schettino, Antonino Oscar Di Tommaso, Rosario Miceli   +5 more
doaj   +1 more source

Characterization of wavelength tunable lasers for future optical communication systems [PDF]

, 2010
The use of tunable lasers (TL) in dense wavelength division multiplexed (DWDM) networks for optical switching, routing and networking has gained a lot of interest in recent years.
Anandarajah, Prince M., Barry, Liam P., Kaszubowska-Anandarajah, Aleksandra, Maher, Robert D., Shi, Kai   +4 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Fixed Switching Frequency Direct Model Predictive Control of Synchronous Reluctance Machines Based on Stator Flux Gradients

IEEE Access
This paper proposes a direct model predictive control method with a fixed switching frequency for stator flux control of a synchronous reluctance machine.
Ivana Zagorscak, Luka Pravica, Igor Erceg, Sandor Iles   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source