Results 181 to 190 of about 36,346 (215)

Immunophilin FK506-Binding Protein 52 (Not FK506-Binding Protein 12) Mediates the Neurotrophic Action of FK506

The Journal of Pharmacology and Experimental Therapeutics, 1999
The neurotrophic property of the immunosuppressant drug FK506 (tacrolimus) is believed to depend on the 12-kDa FK506-binding protein (FKBP-12). Here, we show that FK506 maintains its neurotrophic activity in primary hippocampal cell cultures from FKBP-12 knockout mice.
B G, Gold, V, Densmore, W, Shou, M M, Matzuk, H S, Gordon   +4 more
openaire   +2 more sources

FK506 vs. cyclosporin

Cardiovascular Pathology, 2003
Abstract Introduction: Whether FK506 or cyclosporin is better for chronic immunosuppression in heart transplant patients has been debated. We examined endomyocardial biopsies from patients treated with these two drugs to determine if there was a difference in frequency of histologic cellular rejection episodes and Quilty lesions. The Quilty lesion (
Nupoor A. Gajjar, Jon A. Kobashigawa, Hillel Laks, Maria Espejo-Vassilakis, Michael C. Fishbein   +4 more
openaire   +1 more source

FK506 Treatment of Noninfectious Uveitis

American Journal of Ophthalmology, 1994
We studied the clinical effects of the immunosuppressive agent FK506 in patients with noninfectious uveitis.This study was designed as a multicenter open clinical trial in Japan. Sixteen patients with noninfectious uveitis who had visited the Uveitis Survey Clinic of the Yokohama City University Hospital were given FK506.
M, Ishioka, S, Ohno, S, Nakamura, K, Isobe, N, Watanabe, Y, Ishigatsubo, S, Tanaka   +6 more
openaire   +2 more sources

Oral Absorption of FK506 in Rats

Pharmaceutical Research, 1993
The oral absorption of FK506 in solid dispersion formulation was studied in rats. The obtained area under the concentration versus time curve (AUC) increased in a nonlinear fashion with a small dose-dependent increase in the peak blood concentrations (Cmax).
A, Kagayama, S, Tanimoto, J, Fujisaki, A, Kaibara, K, Ohara, K, Iwasaki, Y, Hirano, T, Hata   +7 more
openaire   +2 more sources

The FK506-binding protein of the malaria parasite, Plasmodium falciparum, is a FK506-sensitive chaperone with FK506-independent calcineurin-inhibitory activity

Molecular and Biochemical Parasitology, 2005
We have identified an immunophilin of the FKBP family in Plasmodium falciparum that contains a conserved peptidyl prolyl isomerase (PPIase) and tetratricopeptide repeat (TPR) domains. The 35 kDa protein was named FKBP35 and expressed in bacteria. Recombinant FKBP35 exhibited potent PPIase and protein folding activities against defined substrates in ...
Rajinder, Kumar, Brian, Adams, Alla, Musiyenko, Olena, Shulyayeva, Sailen, Barik   +4 more
openaire   +2 more sources

Immunosuppression‐induced leukoencephalopathy from tacrolimus (FK506)

Annals of Neurology, 1996
AbstractTacrolimus (FK506) has recently been approved for immunosuppressionin organ transplantation, although its use is accompanied by a wide spectrum ofneurotoxic side effects. We describe the clinical, radiological, and pathological features of 3 cases of tacrolimus‐related leukoencephalopathy.
S L, Small, M B, Fukui, G T, Bramblett, B H, Eidelman   +3 more
openaire   +2 more sources

Distal tubular acidosis induced by FK506

Clinical Transplantation, 1998
This study was designed to investigate the effect of tacrolimus (FK506) and of cyclosporine (CSA) on tubular function in renal graft recipients. Patients were randomised after renal transplantation to immunosuppressive treatment with FK506 (n = 8) or CSA (n = 8).
P, Heering, K, Ivens, S, Aker, B, Grabensee   +3 more
openaire   +2 more sources

FKBP (FK506 Binding Protein)

2016
In the 70s, after a decade from the purification of cyclosporine, a selective immunosuppressant agent and potent tool in transplantation medicine, a novel molecule was purified from bacteria Streptomyces tsukubaensis. This molecule, called FK506, showed the same selective immunosuppressant action as cyclosporine but was 10 to 100 fold more potent.
D'ARRIGO, PAOLO, Tufano, Martina, Rea, Anna, ROMANO, SIMONA, ROMANO, MARIA FIAMMETTA   +4 more
openaire   +2 more sources

FK506-INDUCED KIDNEY TUBULAR CELL INJURY

Transplantation, 1992
Some renal changes associated with cyclosporine, such as tubular vacuolization and glomerular thrombosis, have also been reported with FK506. Furthermore, FK506 therapy is associated with a decrease in glomerular filtration rate and renal plasma flow and an increase in renal vascular resistance. We studied the in vitro tubular cell sensitivity to FK506
ABDELHAKIM MOUTABARRIK, MICHIO ISHIBASHI, MEGUMU FUKUNAGA, HIROSHI KAMEOKA, NAOMASA KAWAGUCHI, YUJI TAKANO, YUKITO KOKADO, TAKAO SONODA, SHUNZO ONISHI, SHIRO TAKAHARA, AKIHIKO OKUYAMA   +10 more
openaire   +2 more sources

FK506‐induced neurotoxicity in liver transplantation

Annals of Neurology, 1994
AbstractWe report FK506‐induced neurotoxicity in 14 of 44 consecutive patients following orthoptic liver transplantation. In 10 of these 14 patients, postural hand tremors were found in the first weeks following surgery, transient apraxia of speech in 3, and generalized tonic‐clonic seizures were noted in 2 patients.
E F, Wijdicks, R H, Wiesner, L J, Dahlke, R A, Krom   +3 more
openaire   +2 more sources