Results 191 to 200 of about 36,346 (215)

Synthesis and pharmacokinetics of a novel macromolecular prodrug of Tacrolimus (FK506), FK506–dextran conjugate

Journal of Controlled Release, 1999
A novel macromolecular prodrug of Tacrolimus (FK506), FK506-dextran conjugate, was developed and its physico-chemical, biological and pharmacokinetic characteristics were studied. The conjugate was estimated to contain 0.45% of FK506 and the coupling molar ratio was approximately 1:1 (dextran-FK-506).
H, Yura, N, Yoshimura, T, Hamashima, K, Akamatsu, M, Nishikawa, Y, Takakura, M, Hashida   +6 more
openaire   +2 more sources

Fluorescent Probes to Characterise FK506‐Binding Proteins

ChemBioChem, 2009
AbstractTalented all‐rounders: Fluorescence polarisation assays were developed for members of the FK506‐binding protein family by using fluorescent rapamycin analogues (demonstrated in the figure). These tracers retain medium to high affinity to all tested proteins (FKBP12, ‐12.6, ‐13, ‐25, ‐51, ‐52).
Kozany, C., Marz, A., Kress, C., Hausch, F.   +3 more
openaire   +3 more sources

FK506 binding protein 12 mediates sensitivity to both FK506 and rapamycin in murine mast cells

European Journal of Immunology, 1995
AbstractThe immunosuppressive drugs FK506 and rapamycin bind to a family of intracellular proteins termed FK506‐binding proteins (FKBP). FK506 and rapamycin inhibit lymphocyte‐activation pathways by forming complexes with an FKBP; subsequently, the drug/FKBP complexes interact with target molecules involved in signal transduction. A key target of FK506/
D A, Fruman, M A, Wood, C K, Gjertson, H R, Katz, S J, Burakoff, B E, Bierer   +5 more
openaire   +2 more sources

FK506, An Immunosuppressant Targeting Calcineurin Function

Current Medicinal Chemistry, 2000
The macrolactam natural product, FK506 (Tacrolimus), acts as a powerful and clinically useful immnosuppressant through disruption of signaling events mediated by the calcium-dependent serine threonine protein phosphatase, calcineurin (CaN), in T lymphocytes.
openaire   +2 more sources

Evaluation of Synthetic FK506 Analogues as Ligands for the FK506-Binding Proteins 51 and 52

Journal of Medicinal Chemistry, 2012
The FK506-binding proteins (FKBP) 51 and 52 are cochaperones that modulate the signal transduction of steroid hormone receptors. Both proteins have been implicated in prostate cancer. Furthermore, single nucleotide polymorphisms in the gene encoding FKBP51 have been associated with a variety of psychiatric disorders.
Ranganath, Gopalakrishnan, Christian, Kozany, Steffen, Gaali, Christoph, Kress, Bastiaan, Hoogeland, Andreas, Bracher, Felix, Hausch   +6 more
openaire   +2 more sources

Comparative efficacy of liposomal FK506 with FK506

Transplantation Proceedings, 1998
S D, Moffatt, V, McAlister, R Y, Calne, S, Metcalfe   +3 more
openaire   +2 more sources

FK506

Transplantation, 1992
openaire   +2 more sources

Development of a macromolecular prodrug of FK506: I. synthesis of FK506-dextran conjugate

Transplantation Proceedings, 1998
H, Yura, N, Yoshimura, T, Hamashima, T, Oka, Y, Takakura, M, Hashida   +5 more
openaire   +2 more sources

FK506: Anti-Inflammatory Properties

Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents, 2003
Kiyoshi Migita, Katsumi Eguchi
openaire   +1 more source

FK506, Artificial Intelligence and Pharmacoeconomics

The Journal of Clinical Pharmacology, 1993
openaire   +2 more sources