Effect on the canine Eck fistula liver of intraportal TGF‐β alone or with hepatic growth factors [PDF]
, 1992 Transforming growth factor‐β canceled the hepatocyte proliferation caused by transforming growth factor‐α when the two substances were mixed and administered through a disconnected central portal vein branch after creation of an Eck fistula. In contrast,
Alessandro Azzarone +28 more
core +1 more source
USP45 and Spindly are part of the same complex implicated in cell migration [PDF]
, 2018 Ubiquitylation is a protein modification implicated in several cellular processes. This process is reversible by the action of deubiquinating enzymes (DUBs).
Conte, Claudia +3 more
core +2 more sources
Phosphorylation of Ryanodine Receptors
Biological Research, 2004 Both cardiac and skeletal muscle ryanodine receptors (RyRs) are parts of large complexes that include a number of kinases and phosphatases. These RyRs have several potential phosphorylation sites in their cytoplasmic domains, but the functional ...
CRISTINA I DANILA, SUSAN L HAMILTON
doaj
Suppression of feline coronavirus replication in vitro by cyclosporin A
Veterinary Research, 2012 The feline infectious peritonitis virus (FIPV) is a member of the feline coronavirus family that causes FIP, which is incurable and fatal in cats. Cyclosporin A (CsA), an immunosuppressive agent that targets the nuclear factor pathway of activated T ...
Tanaka Yoshikazu +5 more
doaj +1 more source
Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity. [PDF]
, 2019 Kinesin force generation involves ATP-induced docking of the neck linker (NL) along the motor core. However, the roles of the proposed steps of NL docking, cover-neck bundle (CNB) and asparagine latch (N-latch) formation, during force generation are ...
Budaitis, Breane G +8 more
core +1 more source
A method to rapidly create protein aggregates in living cells [PDF]
, 2016 The accumulation of protein aggregates is a common pathological hallmark of many neurodegenerative diseases. However, we do not fully understand how aggregates are formed or the complex network of chaperones, proteasomes and other regulatory factors ...
Chen, L-C +7 more
core +1 more source
The Ebola Virus matrix protein, VP40, requires phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) for extensive oligomerization at the plasma membrane and viral egress [PDF]
, 2016 VP40 is one of eight proteins encoded by the Ebola Virus (EBOV) and serves as the primary matrix protein, forming virus like particles (VLPs) from mammalian cells without the need for other EBOV proteins.
Johnson, Kristen A. +3 more
core +1 more source
Trypanosoma cruzi macrophage infectivity potentiator has a rotamase core and a highly exposed α-helix [PDF]
, 2014 The macrophage infectivity potentiator protein from Trypanosoma cruzi (TcMIP) is a major virulence factor secreted by the etiological agent of Chagas' disease. It is functionally involved in host cell invasion.
Coll, Miquel +8 more
core +2 more sources
Short-term recognition memory impairment is associated with decreased expression of FK506 binding protein 51 in the aged mouse brain [PDF]
, 2010 Evidence suggests that increased glucocorticoid receptor (GR) signaling may contribute to cognitive decline with age. We hypothesized that alterations in GR signaling pathway molecules, FK506 binding protein (FKBP) 51 and FKBP52, were associated with ...
Virawudh Soontornniyomkij +6 more
core +1 more source
Leukocyte chemotactic activity of FKBP and inhibition by FK506
Biochemical and Biophysical Research Communications, 1992 Cyclophilin, the cyclosporin A binding protein and member of the immunophilin family of proteins, demonstrates leukocyte chemotactic activity. In this study we demonstrate that FKBP, the FK506 and rapamycin binding protein, also displays leukocyte chemotactic activity. The chemotactic activity of FKBP is inhibited by FK506, however, FK506 was unable to
M C, Leiva, C R, Lyttle
openaire +2 more sources