Results 91 to 100 of about 93,555 (212)
Engineering FKBP-Based Destabilizing Domains to Build Sophisticated Protein Regulation Systems.
PLoS ONE, 2015 Targeting protein stability with small molecules has emerged as an effective tool to control protein abundance in a fast, scalable and reversible manner.
Wenlin An +7 more
doaj +1 more source
Plant Cyclophilins: Multifaceted Proteins With Versatile Roles
Frontiers in Plant Science, 2020 Cyclophilins constitute a family of ubiquitous proteins that bind cyclosporin A (CsA), an immunosuppressant drug. Several of these proteins possess peptidyl-prolyl cis-trans isomerase (PPIase) activity that catalyzes the cis-trans isomerization of the ...
Harpreet Singh +6 more
doaj +1 more source
, 2019 Chemically induced dimerization (CID) has been applied to study numerous biological processes and has important pharmacological applications. However, the complex multistep interactions under various physical constraints involved in CID impose a great ...
Zhenhuan Guo (7349747) +6 more
core +4 more sources
Phosphorylation of Ryanodine Receptors
Biological Research, 2004 Both cardiac and skeletal muscle ryanodine receptors (RyRs) are parts of large complexes that include a number of kinases and phosphatases. These RyRs have several potential phosphorylation sites in their cytoplasmic domains, but the functional ...
CRISTINA I DANILA, SUSAN L HAMILTON
doaj
Suppression of feline coronavirus replication in vitro by cyclosporin A
Veterinary Research, 2012 The feline infectious peritonitis virus (FIPV) is a member of the feline coronavirus family that causes FIP, which is incurable and fatal in cats. Cyclosporin A (CsA), an immunosuppressive agent that targets the nuclear factor pathway of activated T ...
Tanaka Yoshikazu +5 more
doaj +1 more source
, 1995 The trigger factor of Escherichia coli is known as a chaperone protein which forms soluble complexes with the precursor to outer membrane protein A and assists in the maintenance of translocation competence.
Isabelle Callebaut +3 more
core +1 more source
, 1992 The solvent-exposed regions of [U-C-13]ascomycin when bound to its putative target protein, FKBP, have been identified based on the different proton longitudinal relaxation rates (R1 = 1/T1) measured in the absence and presence of the paramagnetic ...
S. W. FESIK, A. M. PETROS, NERI, Placido
core +1 more source
Development of NanoBRET‐Binding Assays for FKBP‐Ligand Profiling in Living Cells
FK506‐binding proteins (FKBPs) are promising targets for a variety of disorders and infectious diseases. High FKBP occupancy is thought to be necessary for ligands to effectively compete with the endogenous intracellular functions of FKBPs.
Walz, Michael +6 more
core +1 more source
Relationship of FKBP to PKCI-2 [PDF]
Nature, 1991 M W, Albers, J, Liu, S L, Schreiber
openaire +2 more sources
Longitudinal studies of trauma in police officers
European Journal of Psychotraumatology, 2012 Background : Results will be presented on a prospective longitudinal study of risk and resilience for post-traumatic stress disorder (PTSD) symptoms in 400 police academy recruits, assessed during academy training and followed during the first 7 years of
Charles Marmar
doaj +1 more source