Results 71 to 80 of about 93,555 (212)

Inducible CRISPR/Cas systems in precision oncology: Current applications and future perspectives

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Inducible CRISPR/Cas systems enable spatiotemporal genome editing in precision oncology. Chemical, optical, physical, and microenvironmental stimuli provide distinct control strategies. Conditional activation may reduce off‐target exposure and basal nuclease activity.
Ziliang Ding, Yukun Wei, Yong Han, Pengfei Gu   +3 more
wiley   +1 more source

Genome-Wide Identification and Analysis of FKBP Gene Family in Wheat (Triticum asetivum)

, 2022
FK506-binding protein (FKBP) genes have been found to play vital roles in plant development and abiotic stress responses. However, limited information is available about this gene family in wheat (Triticum aestivum L.).
Guozhang Kang, Cheng, Mingyue, Mingyue Cheng, Meng, Yanjun, Zhang, Shuya, Kang, Guozhang, Gezi Li, Qiang Ge, Long, Yu, Ge, Qiang, Peng, Peipei, Yu Long, Shuya Zhang, Yanjun Meng, Peipei Peng, Yuan Cao, Cao, Yuan, Li, Gezi   +17 more
core   +1 more source

Engineered FKBP** permits rapid, reversible and tunable regulation of PTEN function in cellular models.

, 2016
(A) FKBP**-PTEN is reversibly regulated in response to Shld1 treatment in cells. U87MG cells stably expressing FKBP**-PTEN were treated with vehicle or with Shld1 (1μM) for 24 h. One set of cells was then washed thoroughly with DMEM and cultured in Shld1-
Karen Liu (778448), Stefanie Gögel (840989), Wenlin An (840987), Rachel E. Jackson (840988), Martin P. Meyer (840990), Paul Hunter (349996), Michiel van Diepen (441441), Britta J. Eickholt (34239)   +7 more
core   +1 more source

FKBP5 associated CD8 T cell infiltration is a novel prognostic biomarker in luminal B breast cancer

Journal of International Medical Research, 2023
Objective To investigate the relationship between FKBP prolyl isomerase 5 ( FKBP5 ) gene expression and CD8 T cells in tumour progression and immunology of the luminal B subtype of breast cancer (LBBC) using bioinformatics analyses.
Fei Tong, Genlin Lu, Jie Zang, Dingji Hao, Wangjue Xu, Jida Chen, Qiong Ding, Hanchu Xiong   +7 more
doaj   +1 more source

Theranostic Advancements in Brain Cancer: Promising Approaches for Emerging Therapy

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Strategies for improving intra‐arterial administration (A) and photodynamic therapy in brain cancer (B). Improving intra‐arterial (IA) administration and photodynamic therapy (PDT) for brain cancer involves enhancing tumor targeting and breaching the blood–brain barrier (BBB). Key strategies include super selective catheterization, using osmotic agents
Bipraban Khanra, Manoj Kumar Sarangi
wiley   +1 more source

Light‐Activated Protein‐Imprinted Hydrogels Capable of Translating Protein Surface Accessibility Into Missing‐Peptide Footprints

Small Structures, Volume 7, Issue 6, June 2026.
Light‐activated protein‐imprinted PFPA‐functionalized hydrogels crosslink captured proteins and report protein surface accessibility as missing‐peptide patterns readable by standard LC‐MS/MS. Mass spectrometry (MS)‐based structural proteomics can reveal higher‐order structural features in complex biological samples, but many covalent footprinting and ...
Eisuke Kanao, Taichi Nihei, Kankichi Kako, Asato Maeda, Damla Ulker, Hiroshi Nishida, Kosuke Ogata, Mingdi Yan, Sergey Piletsky, Yasushi Ishihama, Takuya Kubo   +10 more
wiley   +1 more source

The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13.

Journal of Biological Chemistry, 1992
Extracts from human Jurkat cells or from calf thymus contain a 60-kDa protein that is bound to immobilized FK506. As expected, the NH2-terminal sequences of the 60-kDa protein from these two species were found to be nearly the same. We were surprised to discover, however, that the sequence of the human protein was identical to that of Hsp56, a heat ...
A W, Yem, A G, Tomasselli, R L, Heinrikson, H, Zurcher-Neely, V A, Ruff, R A, Johnson, M R, Deibel   +6 more
openaire   +2 more sources

Master and servant: Regulation of auxin transporters by FKBPs and cyclophilins [PDF]

Plant Science, 2016
Plant development and architecture are greatly influenced by the polar distribution of the essential hormone auxin. The directional influx and efflux of auxin from plant cells depends primarily on AUX1/LAX, PIN, and ABCB/PGP/MDR families of auxin transport proteins. The functional analysis of these proteins has progressed rapidly within the last decade
Geisler, Markus, Bailly, Aurélien, Ivanchenko, Maria   +2 more
openaire   +5 more sources

Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD [PDF]

, 2016
Background: Peptidyl-prolyl isomerases (PPIases) catalyze cis/trans isomerization of peptidyl-prolyl bonds, which is often rate-limiting for protein folding.
Kristofer Modig (1273527), Akke, Mikael,, Loew, Christian, Christian Löw, Ulrich Weininger (1282548), Esben M. Quistgaard, Modig, Kristofer,, Nordlund, Pär, Löw, Christian, Ulrich Weininger, Nordlund, Pär,, Weininger, Ulrich,, Modig, Kristofer, Löw, Christian,, Yonca Ural-Blimke, Weininger, Ulrich, Quistgaard, Esben M., Quistgaard, Esben M.,, Akke, Mikael, Pär Nordlund (161768), Esben Quistgaard (3573584), Mikael Akke, Christian Löw (320481), Pär Nordlund, Yonca Ural-Blimke (3573587), Ural-Blimke, Yonca,, Kristofer Modig, Lund University., Mikael Akke (1273515), Ural-Blimke, Yonca   +29 more
core   +1 more source

Intracellular Delivery of Rapamycin From FKBP Elastin-Like Polypeptides Is Consistent With Macropinocytosis

Frontiers in Pharmacology, 2018
Rapamycin (Rapa) is a highly potent drug; however, its clinical potential is limited by poor solubility, bioavailability, and cytotoxicity. To improve Rapa delivery, our team has fused the cognate protein receptor for Rapa, FKBP12, to high molecular ...
Santosh Peddi, Xiaoli Pan, John Andrew MacKay, John Andrew MacKay, John Andrew MacKay   +4 more
doaj   +1 more source