Results 51 to 60 of about 93,555 (212)

Immunoinformatics‐Based Design of a Multi‐Epitope Vaccine Targeting a Conserved Copper–Associated Protein in Neisseria gonorrhoeae

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
wiley   +1 more source

Increased striatal mRNA and protein levels of the immunophilin FKBP-12 in experimental Parkinson’s Disease and identification of FKBP-12-binding proteins

, 2007
FKBP-12, a 12 kDa FK506-binding protein (neuroimmunophilin), acts as a receptor for the immunosuppressant drug FK506. Neuroimmunophilins, including FKBP-12, are abundant in the brain and have been shown to be involved in reversing neuronal degeneration ...
Sköld, Karl,, Andrén, Per E.,, Sjögren, Benita, Persson, B, Buijs, Jos, Caprioli, RM, Buijs, J, Skold, K, Zhang, X,, Zhang, Xiaoqun, Caprioli, Richard M., Nilsson, A, Sjogren, B, Nilsson, Anna,, Svensson, M, Piersont, J, Svenningsson, P,, Svensson, Marcus,, Svenningsson, Per, Pierson, Johan,, Persson, Björn   +20 more
core   +1 more source

FKBP immunophilins and Alzheimer’s disease: A chaperoned affair

Journal of Biosciences, 2011
The FK506-binding protein (FKBP) family of immunophilins consists of proteins with a variety of protein-protein interaction domains and versatile cellular functions. Analysis of the functions of immunophilins has been the focus of studies in recent years and has led to the identification of various molecular pathways in which FKBPs play an active role.
Weihuan, Cao, Mary, Konsolaki
openaire   +2 more sources

Association of FK506 binding proteins with RyR channels - effect of CLIC2 binding on sub-conductance opening and FKBP binding

, 2020
Ryanodine receptor (RyR) Ca2+ channels are central to striated muscle function and influence signalling in neurons and other cell types. Beneficially low RyR activity and maximum conductance opening may be stabilised when RyRs bind to FK506 binding ...
Richardson, J, Casarotto, Marco, Schwartz, Charles E, Board, Philip, Beard, Nicole, Dulhunty, Angela, Lam, Alexander, Gallant, Esther, Steele, Gregory A.   +8 more
core   +2 more sources

Seeing Invisible Oligomers: Rethinking α‐Synuclein Pathology Through Proximity Ligation Assay

Movement Disorders, EarlyView.
Abstract Parkinson's disease (PD) and multiple system atrophy are defined by α‐synuclein (αSYN)‐positive inclusions – Lewy bodies (LBs) and glial cytoplasmic inclusions – yet mounting evidence indicates that these inclusions represent only a fraction of disease‐relevant pathology.
Hiroaki Sekiya, Nanna Møller Jensen, Dennis W. Dickson, Poul Henning Jensen   +3 more
wiley   +1 more source

Codon optimization of FKBP** establishes a conditional fine-tuning protein regulation system.

, 2016
(A) The transcription of the destabilization cassette FKBP**-PTEN was subcloned downstream of LoxP-Stop-LoxP; transcription was driven by the ubiquitous CMV-enhanced chicken beta actin promoter (CAG).
Karen Liu (778448), Stefanie Gögel (840989), Wenlin An (840987), Rachel E. Jackson (840988), Martin P. Meyer (840990), Paul Hunter (349996), Michiel van Diepen (441441), Britta J. Eickholt (34239)   +7 more
core   +1 more source

HSP-90/kinase complexes are stabilized by the large PPIase FKB-6

Scientific Reports, 2021
Protein kinases are important regulators in cellular signal transduction. As one major type of Hsp90 client, protein kinases rely on the ATP-dependent molecular chaperone Hsp90, which maintains their structure and supports their activation.
Siyuan Sima, Katalin Barkovits, Katrin Marcus, Lukas Schmauder, Stephan M. Hacker, Nils Hellwig, Nina Morgner, Klaus Richter   +7 more
doaj   +1 more source

Utilizing chemically induced dimerization of FKBP to analyze endocytosis by live-cell imaging in budding yeast

STAR Protocols, 2022
Summary: Chemically induced dimerization (CID) is a useful tool for artificially inducing protein-protein interactions. Although CID has been used extensively for live-cell microscopy applications in mammalian systems, it is rarely utilized in yeast cell
Andrew K. Lamb, Santiago M. Di Pietro
doaj   +1 more source

Universal and Lineage‐Specific Patterns in the Distribution of ECOD Domain Homology Groups Across Superkingdoms

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly resolved.
Rui Guo, Jimin Pei, Jing Zhang, Qian Cong, Nick V. Grishin, R. Dustin Schaeffer   +5 more
wiley   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source