Results 31 to 40 of about 93,555 (212)
FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells
Cell Communication and Signaling, 2023 Background The immunophilin FKBP12 binds to TGF-β family type I receptors, including the BMP type I receptor ALK2. FKBP12 keeps the type I receptor in an inactive state and controls signaling activity. Removal of FKBP12 with drugs such as the FKBP-ligand
Ingrid Quist-Løkken +10 more
doaj +1 more source
Structural insights into Plasmodium PPIases
Frontiers in Cellular and Infection Microbiology, 2022 Malaria is one of the most prevalent infectious diseases posing a serious challenge over the years, mainly owing to the emergence of drug-resistant strains, sparking a need to explore and identify novel protein targets.
Sreekanth Rajan +3 more
doaj +1 more source
FKBP51 and FKBP12.6-Novel and tight interactors of Glomulin.
PLoS ONE, 2019 The protein factor Glomulin (Glmn) is a regulator of the SCF (Skp1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. Mutations of Glmn lead to glomuvenous malformations.
Andreas Hähle +6 more
doaj +1 more source
BMC Genomics, 2018 Background The FK506-binding proteins (FKBPs) play diverse roles in numerous critical processes for plant growth, development, and abiotic stress responses.
Qinglong Dong +10 more
doaj +1 more source
Update on the Neisseria Macrophage Infectivity Potentiator-Like PPIase Protein
Frontiers in Cellular and Infection Microbiology, 2022 Neisseria pathogens express a Macrophage Infectivity Potentiator Protein (MIP), which belongs to the FK506 binding protein (FKBP) family of proteins that exhibit peptidyl-prolyl cis/trans isomerase (PPIase) activity.
Myron Christodoulides
doaj +1 more source
Role of FKBPs in Parkinson’s Disease [PDF]
, 2012 Parkinson’s disease (PD) is the second most common neurodegenerative disease among the elderly. While sporadic PD constitutes 99% of the cases, the remaining 1% is of genetic origin. The neuropathological hallmarks of PD are progressive degeneration of dopaminergic (DA) neurons and presence of Lewy neurites and Lewy bodies (LBs) intracytoplasmic ...
Souvik Chattopadhaya +2 more
openaire +1 more source
Engineering a Rapid Insulin Release System Controlled By Oral Drug Administration
Advanced Science, 2022 Rapid insulin release plays an essential role in maintaining blood‐glucose homeostasis in mammalians. Patients diagnosed with type‐I diabetes mellitus experience chronic and remarkably high blood‐sugar levels, and require lifelong insulin injection ...
Mohamed Mahameed +4 more
doaj +1 more source
Frontiers in Plant Science, 2022 Potato is the most important non-grain food in the world, while late blight caused by Phytophthora infestans seriously threatens the production of potato.
Yang Mu +27 more
doaj +1 more source
Anterograde Transport of Rab4-Associated Vesicles Regulates Synapse Organization in Drosophila
Cell Reports, 2017 Local endosomal recycling at synapses is essential to maintain neurotransmission. Rab4GTPase, found on sorting endosomes, is proposed to balance the flow of vesicles among endocytic, recycling, and degradative pathways in the presynaptic compartment ...
Swagata Dey, Gary Banker, Krishanu Ray
doaj +1 more source
NMR assignments of the FKBP-type PPIase domain of FKBP42 from Arabidopsis thaliana [PDF]
, 2012 The Atfkbp42 gene is associated with reduced and disoriented growth of Arabidopsis thaliana. Resonance assignments are reported for the FKBP-type PPIase domain of AtFKBP42.
Geisler, Markus +4 more
core +1 more source