Results 31 to 40 of about 92,716 (181)

Novel cycloheximide derivatives targeting the moonlighting protein Mip exhibit specific antimicrobial activity against Legionella pneumophila

Frontiers in Bioengineering and Biotechnology, 2015
Mip (macrophage infectivity potentiator) and Mip-like proteins are virulence factors in a wide range of pathogens including Legionella pneumophila. These proteins belong to the FK506 binding protein (FKBP) family of peptidyl-prolyl-cis/trans-isomerases ...
Janine eRasch, Martin eTheuerkorn, Can eÜnal, Can eÜnal, Natascha eHeinsohn, Stefan eTran, Gunter eFischer, Gunter eFischer, Matthias eWeiwad, Matthias eWeiwad, Michael eSteinert, Michael eSteinert   +11 more
doaj   +1 more source

Systematic analysis of FKBP inducible degradation domain tagging strategies for the human malaria parasite Plasmodium falciparum. [PDF]

PLoS ONE, 2012
Targeted regulation of protein levels is an important tool to gain insights into the role of proteins essential to cell function and development. In recent years, a method based on mutated forms of the human FKBP12 has been established and used to great ...
Mauro Ferreira de Azevedo, Paul R Gilson, Heloisa B Gabriel, Roseli F Simões, Fiona Angrisano, Jacob Baum, Brendan S Crabb, Gerhard Wunderlich   +7 more
doaj   +1 more source

Genome-Wide Identification of the FKBP Gene Family in Rice and Its Potential Roles in Blast Resistance

Agronomy
Rice (Oryza sativa L.) is a major global staple crop, yet its productivity is severely constrained by rice blast disease caused by Magnaporthe oryzae.
Jiazong Liu, Xin Wang, Wendi Li, Qiyue Xu, Xinhua Ding, Ziyi Yin   +5 more
doaj   +1 more source

Mutations in Hsp90 Cochaperones Result in a Wide Variety of Human Disorders

Frontiers in Molecular Biosciences, 2021
The Hsp90 molecular chaperone, along with a set of approximately 50 cochaperones, mediates the folding and activation of hundreds of cellular proteins in an ATP-dependent cycle.
Jill L. Johnson
doaj   +1 more source

FKBP Family Proteins: Immunophilins with Versatile Biological Functions [PDF]

Neurosignals, 2008
Immunophilins consist of a family of highly conserved proteins binding with immunosuppressive drugs such as FK506, rapamycin and cyclosporin A. FK506-binding protein (FKBP) is one of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity.
Kang, Cong Bao, Ye, Hong, Dhe-Paganon, Sirano, Yoon, Ho Sup   +3 more
openaire   +3 more sources

Peptidylprolyl Isomerases as In Vivo Carriers for Drugs That Target Various Intracellular Entities

Biomolecules, 2017
Analyses of sequences and structures of the cyclosporine A (CsA)-binding proteins (cyclophilins) and the immunosuppressive macrolide FK506-binding proteins (FKBPs) have revealed that they exhibit peculiar spatial distributions of charges, their overall ...
Andrzej Galat
doaj   +1 more source

Multi-Omics Analysis of the Expression and Prognosis for FKBP Gene Family in Renal Cancer

Frontiers in Oncology, 2021
BackgroundThe FK506-binding protein (FKBP) is a family of intracellular receptors that can bind specifically to the immunosuppressant FK506 and rapamycin.
Zeqiang Sun, Xin Qin, Juanjuan Fang, Yueqing Tang, Yidong Fan   +4 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Immunoinformatics‐Based Design of a Multi‐Epitope Vaccine Targeting a Conserved Copper–Associated Protein in Neisseria gonorrhoeae

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
wiley   +1 more source