Results 11 to 20 of about 93,555 (212)
Solution structure of FK506 bound to FKBP‐12 [PDF]
FEBS Letters, 1992 The complex of the immunosuppressant FK506 bound to FKBP‐12 has been studied in solution using 1H and inverse‐detected 13C NMR methods. The resonances of bound, 13C‐labelled FK506 were assigned and a set of 66 intraligand NOE distance restraints were used to calculate the structure of the bound ligand by distance geometry and restrained molecular ...
Lepre, Christopher A. +2 more
openaire +3 more sources
FKBP Family Proteins: Immunophilins with Versatile Biological Functions [PDF]
Neurosignals, 2008 Immunophilins consist of a family of highly conserved proteins binding with immunosuppressive drugs such as FK506, rapamycin and cyclosporin A. FK506-binding protein (FKBP) is one of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity.
Kang, Cong Bao +3 more
openaire +4 more sources
Functions of the Hsp90-Binding FKBP Immunophilins
, 2014 Hsp90 functionally interacts with a broad array of client proteins, but in every case examined Hsp90 is accompanied by one or more co-chaperones. One class of co-chaperone contains a tetratricopeptide repeat domain that targets the co-chaperone to the C-terminal region of Hsp90.
Guy, Naihsuan +4 more
openaire +4 more sources
, 2016 In the 70s, after a decade from the purification of cyclosporine, a selective immunosuppressant agent and potent tool in transplantation medicine, a novel molecule was purified from bacteria Streptomyces tsukubaensis. This molecule, called FK506, showed the same selective immunosuppressant action as cyclosporine but was 10 to 100 fold more potent.
D'ARRIGO, PAOLO +4 more
openaire +3 more sources
BMC GenomicsBackground In plants, FK506-binding proteins (FKBPs) have been shown to participate in various biological processes such as photosynthetic system reaction, stress response, and growth and development.
Jianguang Liu +6 more
doaj +2 more sources
Association between RyR and FKBP in experimental preparations: evidence for negative cooperativity [PDF]
, 2023 Ryanodine receptors (RyR), a class of massive tetrameric intracellular ion channels, are an indispensable element of excitation-contraction coupling, governing the release of Ca2+ from the sarcoplasmic reticulum (SR).
Richardson, Spencer
core +1 more source
FKBPs and the Akt/mTOR pathway [PDF]
Cell Cycle, 2013 FK506-binding proteins (FKBP) belong to the immunophilin family and are best known for their ability to enable the immunosuppressive properties of FK506 and rapamycin. For rapamycin, this is achieved by inducing inhibitory ternary complexes with the kinase mTOR. The essential accessory protein for this gain-of-function was thought to be FKBP12.
Hausch, F. +3 more
openaire +3 more sources
Cell Cycle-Specific Regulation of Centrosome Clustering Dynamics in Cancer Cells by the Multifunctional Kinesin HSET. [PDF]
Adv Sci (Weinh)CDK5RAP2 associates with the kinesin HSET and forms co‐condensates. HSET motors drive the directional transport of CDK5RAP2 condensates toward microtubule minus ends. During mitosis, HSET self‐assembly further stabilizes clustered centrosomes, thereby enabling pseudo‐bipolar spindle formation in cancer cells with supernumerary centrosomes. Upon mitotic
Chen PP +11 more
europepmc +2 more sources
Studies on FKBP ligands and inhibitors for GS-like enzymes [PDF]
, 2023 The first half of this dissertation is dedicated to the development of novel FKBP ligands, aiming to improve binding affinity, selectivity between selected members of the FKBP family, and metabolic stability.
Purder, Patrick
core +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source