Results 41 to 50 of about 93,555 (212)
Frontiers in Bioengineering and Biotechnology, 2015 Mip (macrophage infectivity potentiator) and Mip-like proteins are virulence factors in a wide range of pathogens including Legionella pneumophila. These proteins belong to the FK506 binding protein (FKBP) family of peptidyl-prolyl-cis/trans-isomerases ...
Janine eRasch +11 more
doaj +1 more source
FKBP surface engineering restores PTEN activity of FKBP**-PTEN fusion protein.
, 2016 (A) Electrostatic potential map of PTEN (PDB ID: 1d5r) and FKBP (PDB ID: 1BL4). Positively charged binding pocket of the PTEN PIP3 substrate is circled with a white dashed line; the negatively charged lump formed by E31/D32 residues on the FKBP surface ...
Karen Liu (778448) +7 more
core +1 more source
AgronomyRice (Oryza sativa L.) is a major global staple crop, yet its productivity is severely constrained by rice blast disease caused by Magnaporthe oryzae.
Jiazong Liu +5 more
doaj +1 more source
Systematic analysis of FKBP inducible degradation domain tagging strategies for the human malaria parasite Plasmodium falciparum. [PDF]
PLoS ONE, 2012 Targeted regulation of protein levels is an important tool to gain insights into the role of proteins essential to cell function and development. In recent years, a method based on mutated forms of the human FKBP12 has been established and used to great ...
Mauro Ferreira de Azevedo +7 more
doaj +1 more source
Mutations in Hsp90 Cochaperones Result in a Wide Variety of Human Disorders
Frontiers in Molecular Biosciences, 2021 The Hsp90 molecular chaperone, along with a set of approximately 50 cochaperones, mediates the folding and activation of hundreds of cellular proteins in an ATP-dependent cycle.
Jill L. Johnson
doaj +1 more source
Development of NanoBRET‐Binding Assays for FKBP‐Ligand Profiling in Living Cells
, 2021 FK506‐binding proteins (FKBPs) are promising targets for a variety of disorders and infectious diseases. High FKBP occupancy is thought to be necessary for ligands to effectively compete with the endogenous intracellular functions of FKBPs.
Thomas M. Geiger +13 more
core +1 more source
Neuronal regeneration enhances the expression of the immunophilin FKBP- 12
, 1995 Immunophilins are a group of proteins that serve as receptors for the immunosuppressant drugs cyclosporin A and FK506. The immunophilin designated FK-506 binding protein-12 (FKBP-12) is concentrated more than 10 times higher in the brain than in immune ...
TM Dawson +3 more
core +1 more source
Peptidylprolyl Isomerases as In Vivo Carriers for Drugs That Target Various Intracellular Entities
Biomolecules, 2017 Analyses of sequences and structures of the cyclosporine A (CsA)-binding proteins (cyclophilins) and the immunosuppressive macrolide FK506-binding proteins (FKBPs) have revealed that they exhibit peculiar spatial distributions of charges, their overall ...
Andrzej Galat
doaj +1 more source
Multi-Omics Analysis of the Expression and Prognosis for FKBP Gene Family in Renal Cancer
Frontiers in Oncology, 2021 BackgroundThe FK506-binding protein (FKBP) is a family of intracellular receptors that can bind specifically to the immunosuppressant FK506 and rapamycin.
Zeqiang Sun +4 more
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source