Results 61 to 70 of about 92,716 (181)

Theranostic Advancements in Brain Cancer: Promising Approaches for Emerging Therapy

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Strategies for improving intra‐arterial administration (A) and photodynamic therapy in brain cancer (B). Improving intra‐arterial (IA) administration and photodynamic therapy (PDT) for brain cancer involves enhancing tumor targeting and breaching the blood–brain barrier (BBB). Key strategies include super selective catheterization, using osmotic agents
Bipraban Khanra, Manoj Kumar Sarangi
wiley   +1 more source

Classification of rice (oryza sativa l. japonica nipponbare) immunophilins (fkbps, cyps) and expression patterns under water stress

BMC Plant Biology, 2010
Background FK506 binding proteins (FKBPs) and cyclophilins (CYPs) are abundant and ubiquitous proteins belonging to the peptidyl-prolyl cis/trans isomerase (PPIase) superfamily, which regulate much of metabolism through a chaperone or an isomerization of
Luan Sheng, Kim Beom-Gi, Hwang Hyunsik, Park Jeong, Seok Min, You Young, Kim Dae-Won, Ahn Jun, Park Hong-Seog, Cho Hye   +9 more
doaj   +1 more source

PfSWIB, a potential chromatin regulator for var gene regulation and parasite development in Plasmodium falciparum

Parasites & Vectors, 2020
Background Various transcription factors are involved in the process of mutually exclusive expression and clonal variation of the Plasmodium multigene (var) family. Recent studies revealed that a P.
Wei-Feng Wang, Yi-Long Zhang
doaj   +1 more source

Light‐Activated Protein‐Imprinted Hydrogels Capable of Translating Protein Surface Accessibility Into Missing‐Peptide Footprints

Small Structures, Volume 7, Issue 6, June 2026.
Light‐activated protein‐imprinted PFPA‐functionalized hydrogels crosslink captured proteins and report protein surface accessibility as missing‐peptide patterns readable by standard LC‐MS/MS. Mass spectrometry (MS)‐based structural proteomics can reveal higher‐order structural features in complex biological samples, but many covalent footprinting and ...
Eisuke Kanao, Taichi Nihei, Kankichi Kako, Asato Maeda, Damla Ulker, Hiroshi Nishida, Kosuke Ogata, Mingdi Yan, Sergey Piletsky, Yasushi Ishihama, Takuya Kubo   +10 more
wiley   +1 more source

OsFKBP20‐1b stabilizes OsUPF1 and OsUPF2 to promote the degradation of aberrant mRNAs during dehydration stress

Journal of Integrative Plant Biology, Volume 68, Issue 6, Page 1672-1691, June 2026.
The rice protein OsFKBP20‐1b protects key RNA‐surveillance factors from breakdown, so they can better eliminate defective messages. This RNA quality‐control boost reduces errors and helps plants survive drought, revealing a link between RNA control and drought tolerance.
Haemyeong Jung, Hyun Ji Park, Seung Hee Jo, Ki‐Hong Jung, Choonkyun Jung, Hye Sun Cho   +5 more
wiley   +1 more source

HSP90 differentially stabilizes plant ABCB-type auxin transporters on the plasma membrane

Nature Communications
Closely related FKBP orthologs, FKBP42/TWISTED DWARF1 (TWD1) and FKBP38, have been shown to control the biogenesis of plant and mammalian ATP-binding cassette (ABC) transporters, respectively.
Tashi Tsering, Martin Di Donato, Despina Samakovli, Dimitra Milioni, Francesca Romana Iacobini, Konstantinos Panagiotopoulos, Panagiota-Konstantinia Plitsi, Elisa Azarello, Stefano Mancuso, Vendula Pukyšová, Marta Zwiewka, Tomasz Nodzynski, Michael Stumpe, Jutta Ludwig-Müller, Aurélien Bailly, Polydefkis Hatzopoulos, Markus M. Geisler   +16 more
doaj   +1 more source

Material‐Induced Nuclear Deformation Controls Chromatin Architecture in Adipose Stem Cells

Advanced Science, Volume 13, Issue 30, 28 May 2026.
Tuning cell and cytoskeleton mechanics modulated nuclear shape and heterochromatin organization in ASCs. Distinct cytoskeletal architectures induced nuclear morphologies from oblate to prolate ellipsoids. Large elongated cells with a structured actin cap exhibited high nuclear strain, driving nuclear envelope deformation and heterochromatin ...
Carlo F. Natale, Luca Messina, Valeria Panzetta, Stefania Saporito, Costantino Menna, Maurizio Ventre, Paolo A. Netti   +6 more
wiley   +1 more source

Engineering FKBP-Based Destabilizing Domains to Build Sophisticated Protein Regulation Systems.

PLoS ONE, 2015
Targeting protein stability with small molecules has emerged as an effective tool to control protein abundance in a fast, scalable and reversible manner.
Wenlin An, Rachel E Jackson, Paul Hunter, Stefanie Gögel, Michiel van Diepen, Karen Liu, Martin P Meyer, Britta J Eickholt   +7 more
doaj   +1 more source

Plant Cyclophilins: Multifaceted Proteins With Versatile Roles

Frontiers in Plant Science, 2020
Cyclophilins constitute a family of ubiquitous proteins that bind cyclosporin A (CsA), an immunosuppressant drug. Several of these proteins possess peptidyl-prolyl cis-trans isomerase (PPIase) activity that catalyzes the cis-trans isomerization of the ...
Harpreet Singh, Harpreet Singh, Kirandeep Kaur, Mangaljeet Singh, Gundeep Kaur, Gundeep Kaur, Prabhjeet Singh   +6 more
doaj   +1 more source

Phosphorylation of Ryanodine Receptors

Biological Research, 2004
Both cardiac and skeletal muscle ryanodine receptors (RyRs) are parts of large complexes that include a number of kinases and phosphatases. These RyRs have several potential phosphorylation sites in their cytoplasmic domains, but the functional ...
CRISTINA I DANILA, SUSAN L HAMILTON
doaj