Results 81 to 90 of about 93,555 (212)

OsFKBP20‐1b stabilizes OsUPF1 and OsUPF2 to promote the degradation of aberrant mRNAs during dehydration stress

Journal of Integrative Plant Biology, Volume 68, Issue 6, Page 1672-1691, June 2026.
The rice protein OsFKBP20‐1b protects key RNA‐surveillance factors from breakdown, so they can better eliminate defective messages. This RNA quality‐control boost reduces errors and helps plants survive drought, revealing a link between RNA control and drought tolerance.
Haemyeong Jung, Hyun Ji Park, Seung Hee Jo, Ki‐Hong Jung, Choonkyun Jung, Hye Sun Cho   +5 more
wiley   +1 more source

FKBP, the Binding Protein for the Immunosuppressive Drug, FK-506, Is Not an Inhibitor of Protein Kinase C Activity

, 1991
Recently, the amino acid sequence of a 12 Kd endogenous protein inhibitor of protein kinase C (PKC-I 2) has been shown to be identical to that of the 12 KDa receptor for the immunosuppressive drug, FK-506.
Sigal, Nolan H., Wiederrecht, Gregory, Cryan, John G., Hung, Shirley H Y, Siekierka, John   +4 more
core   +1 more source

Material‐Induced Nuclear Deformation Controls Chromatin Architecture in Adipose Stem Cells

Advanced Science, Volume 13, Issue 30, 28 May 2026.
Tuning cell and cytoskeleton mechanics modulated nuclear shape and heterochromatin organization in ASCs. Distinct cytoskeletal architectures induced nuclear morphologies from oblate to prolate ellipsoids. Large elongated cells with a structured actin cap exhibited high nuclear strain, driving nuclear envelope deformation and heterochromatin ...
Carlo F. Natale, Luca Messina, Valeria Panzetta, Stefania Saporito, Costantino Menna, Maurizio Ventre, Paolo A. Netti   +6 more
wiley   +1 more source

Elucidating the Substrate Specificity and Condensation Domain Activity of FkbP, the FK520 Pipecolate-Incorporating Enzyme^†

, 2016
Rapamycin, FK506, and FK520 are potent immunosuppressant natural product macrocycles generated by hybrid polyketide synthase (PKS)/nonribosomal peptide synthetase (NRPS) systems in streptomycetes. An important functional element within these molecules is
Neil L. Kelleher (548328), Christopher T. Walsh (1265718), Shaun M. McLoughlin (2665672), Gregory J. Gatto, (2534206)   +3 more
core   +1 more source

Classification of rice (oryza sativa l. japonica nipponbare) immunophilins (fkbps, cyps) and expression patterns under water stress

BMC Plant Biology, 2010
Background FK506 binding proteins (FKBPs) and cyclophilins (CYPs) are abundant and ubiquitous proteins belonging to the peptidyl-prolyl cis/trans isomerase (PPIase) superfamily, which regulate much of metabolism through a chaperone or an isomerization of
Luan Sheng, Kim Beom-Gi, Hwang Hyunsik, Park Jeong, Seok Min, You Young, Kim Dae-Won, Ahn Jun, Park Hong-Seog, Cho Hye   +9 more
doaj   +1 more source

PfSWIB, a potential chromatin regulator for var gene regulation and parasite development in Plasmodium falciparum

Parasites & Vectors, 2020
Background Various transcription factors are involved in the process of mutually exclusive expression and clonal variation of the Plasmodium multigene (var) family. Recent studies revealed that a P.
Wei-Feng Wang, Yi-Long Zhang
doaj   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, Volume 13, Issue 27, 13 May 2026.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Sensing and Reprogramming Surface Receptor Activation With Synthetic Transcriptional Circuits

Advanced Science, Volume 13, Issue 25, 4 May 2026.
A synthetic receptor‐signalling induced transcription (RESIT) circuit is designed based on receptor activation mediated split protease complementation and release of membrane‐tethered synthetic transcriptional modules. The RESIT system enables probing Ca2+ entry, receptor tyrosine kinase (RTK) activities and Ras activation, and reprogramming RTK ...
Fei Liu, Mei Yuan, Li‐Juan Tang, Fenglin Wang, Xia Chu, Jian‐Hui Jiang   +5 more
wiley   +1 more source

Penetrating Exploration of Prognostic Correlations of the FKBP Gene Family with Lung Adenocarcinoma

, 2022
The complexity of lung adenocarcinoma (LUAD), the development of which involves many interacting biological processes, makes it difficult to find therapeutic biomarkers for treatment.
Do Xuan, Anuraga, Gangga, Xuan, Do Thi Minh, Hoang Khoa Ta, Wang, Chin-Chou, Wei-Jan Wang, Wang, Wei-Jan, Chiu-Fan Shen, Chin-Chou Wang, Wan-Jou Shen, Gangga Anuraga, Hsieh, Yu-Hsiu, Chih-Yang Wang, Shen, Wan-Jou, Wang, Chih-Yang, Khoa Ta, Hoang Dang, Yu-Hsiu Hsieh, Shen, Chiu-Fan   +17 more
core   +1 more source

HSP90 differentially stabilizes plant ABCB-type auxin transporters on the plasma membrane

Nature Communications
Closely related FKBP orthologs, FKBP42/TWISTED DWARF1 (TWD1) and FKBP38, have been shown to control the biogenesis of plant and mammalian ATP-binding cassette (ABC) transporters, respectively.
Tashi Tsering, Martin Di Donato, Despina Samakovli, Dimitra Milioni, Francesca Romana Iacobini, Konstantinos Panagiotopoulos, Panagiota-Konstantinia Plitsi, Elisa Azarello, Stefano Mancuso, Vendula Pukyšová, Marta Zwiewka, Tomasz Nodzynski, Michael Stumpe, Jutta Ludwig-Müller, Aurélien Bailly, Polydefkis Hatzopoulos, Markus M. Geisler   +16 more
doaj   +1 more source