Results 241 to 250 of about 1,081,696 (319)

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

Advanced Science, EarlyView.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen, Xiao‐Dan Ma, Shui‐Dan Xu, Ao‐Tian Mo, Min‐Hua Deng, Jun‐Han Wu, Wei‐Tao Zhuang, Jin‐Ling Duan, Shu‐Huan Xie, Jin‐Long Lin, Peng Lin, Ji‐Ming Tang, Hai‐Yu Zhou, Xiao‐Song Ben, Gui‐Bin Qiao, Dan Xie   +15 more
wiley   +1 more source

Exogenous Epstein-Barr virus nuclear antigen 1 induces ADAR1-driven tumor resistance against immunotherapy. [PDF]

Signal Transduct Target Ther
Liu C, Sun Z, Li C, Zhou Y, Gao X, Zhong Y, Luo X, Wang C, Zhang Y, Ni C, Peng M, Jian W, Yang Y, Zhang X, Ren Y, Gong X, Zhao M, Guo X, Cheng C, Chen J, Li X.   +20 more
europepmc   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Generation of Schlafen 8-Specific Antibodies. [PDF]

Antibodies (Basel)
Silva-Espinoza JC, Rodriguez Rodriguez MI, Perucho CE, Terrazas BA, Valenzuela C, Palos Vargas S, Carlin A, Prospero DL, Francia G, Llano M.   +9 more
europepmc   +1 more source

MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity

Advanced Science, EarlyView.
During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen, Paili Lin, Yongfang Xia, Zhiqiang Liu, Zilu Cheng, Qingmei Zhu, Shiqi Wan, Xiaoyu Chen, Haiyan Bao, Renbo Qiao, Gechang Zhong, Ying Zhu, Shi Liu   +12 more
wiley   +1 more source

A lysine-free REC tag system for proximity-biotinylation applications. [PDF]

Sci Rep
Tokunaga S, Nagaoka H, Ozawa T, Yamada K, Takeda H, Fujisaki H, Hamada M, Soga F, Kishi H, Takashima E, Sawasaki T.   +10 more
europepmc   +1 more source

Dual‐Key Genetic Circuit Enables Stable and Self‐Regulated Engineered Bacteria for the Treatment of Ulcerative Colitis

Advanced Science, EarlyView.
A self‐regulated Escherichia coli Nissle 1917 strain equipped with a dual‐key genetic circuit achieved antibiotic‐free stability and programmable lysis for therapeutic protein delivery. By co‐expressing an IL‐2 mutant and Amuc_1100, the engineered bacteria restored immune balance and epithelial integrity, providing a safe and precise approach for ...
Shuaijie Ding, Biao Yang, Xinyu Li, Yi Wang, Chunyu Huang, Wenfei Dong, Wei Xie   +6 more
wiley   +1 more source

FBXW7 E3 ligase prevents centriole overduplication by degrading the Plk4 phosphorylated STIL-SAS6 cartwheel assembly. [PDF]

J Biol Chem
Anand U, Bloomberg A, Bhattacharjee P, Mukhopadhyay S, Badarudeen B, Ramakrishnan S, Ben-David U, Manna TK.   +7 more
europepmc   +1 more source

RNF20 dynamically regulates RIG-I and MDA5 transcription and degradation via nucleocytoplasmic translocation to balance antiviral signaling. [PDF]

PLoS Pathog
Wang J, Liu Q, Zhao S, Shao Q, Fu F, Zhang K, Ma J, Wang Z, Yan Y, Wang H, Cheng Y, Sun J.   +11 more
europepmc   +1 more source