Results 111 to 120 of about 37,829 (243)
Immunization with Bivalent Flagellin Protects Mice against Fatal Pseudomonas aeruginosa Pneumonia
Journal of Immunology Research, 2017 Pseudomonas aeruginosa lung infections present a major challenge to healthcare systems worldwide because they are commonly associated with high morbidity and mortality.
Bahador Behrouz +6 more
doaj +1 more source
Microbiome—pancreatic cancer crosstalk: From tumor biology to therapeutic intervention
iMetaOmics, Volume 3, Issue 3, September 2026.The intratumoral microbiome acts as a critical regulator in pancreatic cancer progression and therapeutic resistance. This comprehensive review delineates the origins of pancreatic microbes, elucidates their multifaceted mechanisms in driving immune suppression, metabolic reprogramming, and stromal desmoplasia, and highlights the clinical potential of ...
Yuqin Xie +12 more
wiley +1 more source
Compartmentalized Antimicrobial Defenses in Response to Flagellin
, 2017 International audienceMotility is often a pathogenicity determinant of bacteria targeting mucosal tissues. Flagella constitute the machinery that propels bacteria into appropriate niches. Besides motility, the structural component, flagellin, which forms
Jean-Claude Sirard +7 more
core +1 more source
Inflammatory Bowel Disease: Mechanisms and Therapeutic Advances
MedComm, Volume 7, Issue 9, September 2026.Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is a rising, multifactorial chronic disorder driven by dysregulated mucosal immunity in genetically susceptible individuals and influenced by environmental and microbial factors.
Andrea Papait +5 more
wiley +1 more source
DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy
MedComm, Volume 7, Issue 9, September 2026.This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu +6 more
wiley +1 more source
Communications BiologySeveral bacterial flagellins are O-glycosylated with nonulosonic acids on surface-exposed Serine/Threonine residues by Maf glycosyltransferases. The Clostridium botulinum Maf glycosyltransferase (CbMaf) displays considerable donor substrate promiscuity ...
Sonali Sunsunwal +3 more
doaj +1 more source
Tissue‐Resident Macrophage in Inflammation and Cancer
MedComm, Volume 7, Issue 9, September 2026.Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang +13 more
wiley +1 more source
Plasma levels of anti-flagellin antibodies.
, 2013 A significant reduction of anti-flagellin IgG levels was seen after 72 weeks of antiretroviral treatment compared to baseline in the whole cohort. Plasma levels of anti-flagellin IgG decreased significantly in lopinavir/r (LPV/r) treated patients, but ...
Tatsuo Kanda (234184) +10 more
core +1 more source
MedComm, Volume 7, Issue 9, September 2026.Microbial signals from gut and tumor‐resident bacteria, fungi, viruses, and bacteriophages reshape immune and metabolic networks within the tumor microenvironment, thereby influencing cancer progression, treatment response. Therapeutic modulations, including dietary interventions, probiotics, antibiotics, fecal microbiota transplantation, engineered ...
Juan Lu +8 more
wiley +1 more source