Results 1 to 10 of about 670 (133)
Role of TLR5 and flagella in bacillus intraocular infection. [PDF]
PLoS ONE, 2014 B. cereus possesses flagella which allow the organism to migrate within the eye during a blinding form of intraocular infection called endophthalmitis. Because flagella is a ligand for Toll-like receptor 5 (TLR5), we hypothesized that TLR5 contributed to
Salai Madhumathi Parkunan +2 more
doaj +4 more sources
Frontiers in ImmunologyIntroductionThe incidence of the autoimmune disease, type 1 diabetes (T1D), has been increasing worldwide and recent studies have shown that the gut microbiota are associated with modulating susceptibility to T1D.
Li Wen +2 more
exaly +3 more sources
Role of Toll-Like Receptor 5 in the Development of Ulcerative Colitis [PDF]
Archives of Razi Institute, 2021 Inflammatory bowel disease (ulcerative colitis and Crohn’s disease) is a remitting and relapsing disease that affects millions of people worldwide. In the intestine, homeostasis between repair and signaling of the proinflammatory of the immune system is ...
A Falah Alshimerry +2 more
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The role of Toll-like receptors in chemoradiotherapy-induced gastrointestinal mucositis
口腔疾病防治, 2021 Mucositis is a common gastrointestinal complication in cancer patients undergoing chemoradiotherapy, including oral mucositis and gastrointestinal mucositis, with clinical manifestations of oral ulcers, vomiting, diarrhea and pain that seriously reduce ...
JI Ling +3 more
doaj +1 more source
Frontiers in Oncology, 2021 In this study, GFP-tagged TNBC 4T1 cells with down-regulated TLR5 expression (TLR5− 4T1) and normal TLR5 expression (TLR5+ 4T1) were constructed, respectively.
Wen Jiang +5 more
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Toll-like receptor 5-mediated signaling enhances liver regeneration in mice
Military Medical Research, 2021 Background Toll-like receptor 5 (TLR5)-mediated pathways play critical roles in regulating the hepatic immune response and show hepatoprotective effects in mouse models of hepatic diseases.
Wen Zhang +14 more
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Regulation of Toll-like receptor 5 gene expression and function on mucosal dendritic cells. [PDF]
PLoS ONE, 2012 Toll-like receptor (TLR) 5 has been shown to maintain intestinal homeostasis and regulate host defense against enterobacterial infection. However, how TLR5 expression is regulated and its function in the intestine have not been fully elucidated.
Ting Feng +3 more
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Toll-like receptor 5 tunes hepatic and pancreatic stellate cells activation
BMJ Open Gastroenterology, 2023 Objective Stellate cells are responsible for liver and pancreas fibrosis and strictly correlate with tumourigenesis. Although their activation is reversible, an exacerbated signalling triggers chronic fibrosis.
Malte Buchholz +6 more
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PLoS ONE, 2021 The toll-like receptor 5 (TLR5) is the most conserved important pattern recognition receptors (PRRs) often stimulated by bacterial flagellins and plays a major role in the first-line defense against invading pathogenic bacteria and in immune homeostasis.
Ajaya Kumar Rout +8 more
doaj +1 more source
Deglycosylation of eukaryotic-expressed flagellin restores adjuvanticity
npj Vaccines, 2023 Flagellin, the TLR5 agonist, shows potent adjuvant activities in diverse vaccines and immunotherapies. Vibrio vulnificus flagellin B expressed in eukaryotic cells (eFlaB) could not stimulate TLR5 signaling. Enzymatic deglycosylation restored eFlaB’s TLR5
Koemchhoy Khim +7 more
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