Results 11 to 20 of about 16,392 (208)
TLR5 influences the development of type 1 diabetes [PDF]
BMJ Open Diabetes Research & CareResearch design and methods We investigated mRNA from the islets of Langerhans in patients with newly diagnosed T1D for TLR5 gene expression, as well as Tlr5 and Cd3 expression in the whole pancreatic tissue of female diabetic non-obese diabetic (NOD ...
Knut Dahl-Jørgensen +6 more
doaj +6 more sources
Role of TLR5 and flagella in bacillus intraocular infection. [PDF]
PLoS ONE, 2014 B. cereus possesses flagella which allow the organism to migrate within the eye during a blinding form of intraocular infection called endophthalmitis. Because flagella is a ligand for Toll-like receptor 5 (TLR5), we hypothesized that TLR5 contributed to
Salai Madhumathi Parkunan +2 more
doaj +5 more sources
MAP1S controls breast cancer cell TLR5 signaling pathway and promotes TLR5 signaling-based tumor suppression. [PDF]
PLoS ONE, 2014 Targeting TLR5 signaling in breast cancer represents a novel strategy in cancer immunotherapy. However, the underlying mechanism by which TLR5 signaling inhibits cancer cell proliferation and tumor growth has not been elucidated.
Ming Shi +4 more
doaj +5 more sources
TLR5 Supports Development of Placental Labyrinthine Zone in Mice [PDF]
Frontiers in Cell and Developmental Biology, 2021 Toll plays an important role in innate immunity and embryonic development in lower-ranked animals, but in mammals, the homolog toll-like receptors (TLR) are reported to facilitate postnatal development of immunity only. Here, we discovered a role of TLR5
Jensen H. C. Yiu +18 more
doaj +5 more sources
T4SS-dependent TLR5 activation by Helicobacter pylori infection [PDF]
Nature Communications, 2019 Toll-like receptor TLR5 recognizes a domain, D1, that is present in flagellins of several pathogenic bacteria but not in Helicobacter pylori. Here, the authors show that TLR5 can be activated independently of flagellin by a component of the H.
Suneesh Kumar Pachathundikandi +13 more
doaj +8 more sources
Structural Basis of TLR5-Flagellin Recognition and Signaling [PDF]
Science, 2012 Flagellin Takes Its Toll The immune system recognizes bacterial infections by binding to conserved molecular fragments derived from the invading bacteria. Molecular mimics of these bacterial determinants have the potential to boost the immunogenicity of vaccines. Yoon
Sung-il, Yoon +6 more
core +9 more sources
Role of Toll-Like Receptor 5 in the Development of Ulcerative Colitis [PDF]
Archives of Razi Institute, 2021 Inflammatory bowel disease (ulcerative colitis and Crohn’s disease) is a remitting and relapsing disease that affects millions of people worldwide. In the intestine, homeostasis between repair and signaling of the proinflammatory of the immune system is ...
A Falah Alshimerry +2 more
doaj +2 more sources
Frontiers in Oncology, 2021 In this study, GFP-tagged TNBC 4T1 cells with down-regulated TLR5 expression (TLR5− 4T1) and normal TLR5 expression (TLR5+ 4T1) were constructed, respectively.
Wen G Jiang, Feng Gao, Guihua Hou
exaly +3 more sources
Impaired TLR5 Functionality Is Associated with Survival in Melioidosis [PDF]
The Journal of Immunology, 2013 Abstract Melioidosis is infection caused by the flagellated saprophyte Burkholderia pseudomallei. TLR5 is a pathogen recognition receptor activated by bacterial flagellin. We studied a genetic variant that encodes a defective TLR5 protein, TLR51174C>T, to elucidate the role of TLR5 in melioidosis.
West, T +10 more
openaire +4 more sources
Characterisation and functional analysis of canine TLR5 [PDF]
Innate Immunity, 2020 In this study, we characterised the single exon TLR5 gene of the Chinese rural dog. Sequence analysis revealed a 2577 nucleotide-long open reading frame of canine TLR5, encoding an 858 amino acid-long protein.
Aihua Zhu +6 more
doaj +3 more sources