Results 11 to 20 of about 670 (133)
Characterisation and functional analysis of canine TLR5 [PDF]
Innate Immunity, 2020 In this study, we characterised the single exon TLR5 gene of the Chinese rural dog. Sequence analysis revealed a 2577 nucleotide-long open reading frame of canine TLR5, encoding an 858 amino acid-long protein.
Aihua Zhu +6 more
doaj +3 more sources
MAP1S controls breast cancer cell TLR5 signaling pathway and promotes TLR5 signaling-based tumor suppression. [PDF]
PLoS ONE, 2014 Targeting TLR5 signaling in breast cancer represents a novel strategy in cancer immunotherapy. However, the underlying mechanism by which TLR5 signaling inhibits cancer cell proliferation and tumor growth has not been elucidated.
Ming Shi +4 more
doaj +4 more sources
TLR5 Supports Development of Placental Labyrinthine Zone in Mice [PDF]
Frontiers in Cell and Developmental Biology, 2021 Toll plays an important role in innate immunity and embryonic development in lower-ranked animals, but in mammals, the homolog toll-like receptors (TLR) are reported to facilitate postnatal development of immunity only. Here, we discovered a role of TLR5
Jensen H. C. Yiu +18 more
doaj +3 more sources
TLR5 influences the development of type 1 diabetes [PDF]
BMJ Open Diabetes Research & CareResearch design and methods We investigated mRNA from the islets of Langerhans in patients with newly diagnosed T1D for TLR5 gene expression, as well as Tlr5 and Cd3 expression in the whole pancreatic tissue of female diabetic non-obese diabetic (NOD ...
Knut Dahl-Jørgensen +6 more
doaj +3 more sources
T4SS-dependent TLR5 activation by Helicobacter pylori infection [PDF]
Nature Communications, 2019 Toll-like receptor TLR5 recognizes a domain, D1, that is present in flagellins of several pathogenic bacteria but not in Helicobacter pylori. Here, the authors show that TLR5 can be activated independently of flagellin by a component of the H.
Suneesh Kumar Pachathundikandi +13 more
doaj +5 more sources
TRIF Modulates TLR5-dependent Responses by Inducing Proteolytic Degradation of TLR5 [PDF]
Journal of Biological Chemistry, 2010 Proteolytic modification of pattern recognition receptors and their signaling adaptor molecules has recently emerged as an essential cellular event to regulate immune and inflammatory responses. Here we show that the TIR domain containing adaptor-inducing interferon-beta (TRIF), an adaptor molecule mediating TLR3 signaling and MyD88-independent ...
Yoon Jeong, Choi +3 more
openaire +2 more sources
TLR5 Stops Commensals in Their Tracks [PDF]
Cell Host & Microbe, 2013 IgA antibodies help maintain intestinal immune homeostasis with resident commensal species; however, the precise mechanisms regulating IgA induction and the epitopes recognized by these antibodies remain incompletely understood. In this issue of Cell Host & Microbe, Tyler et al.
Koch, Meghan A., Barton, Gregory M.
openaire +2 more sources
Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella
Frontiers in Immunology, 2020 Leptospira (L.) interrogans are invasive bacteria responsible for leptospirosis, a worldwide zoonosis. They possess two periplasmic endoflagellae that allow their motility. L. interrogans are stealth pathogens that escape the innate immune recognition of
Marion Holzapfel +31 more
doaj +1 more source
Journal of Immunology Research, 2021 Enterogenous infection is a major cause of death during traumatic hemorrhagic shock (THS). It has been reported that Toll-like receptor 5 (TLR5) plays an integral role in regulating mucosal immunity and intestinal homeostasis of the microbiota.
Yun Zhang +10 more
doaj +1 more source
TLR5 risk-associated haplotype for canine inflammatory bowel disease confers hyper-responsiveness to flagellin. [PDF]
PLoS ONE, 2012 Single nucleotide polymorphisms (SNP) in the TLR5 gene have been associated with human inflammatory bowel disease (IBD) and animal models of this disease.
Aarti Kathrani +6 more
doaj +1 more source