Results 11 to 20 of about 14,414 (179)

Characterisation and functional analysis of canine TLR5 [PDF]

Innate Immunity, 2020
In this study, we characterised the single exon TLR5 gene of the Chinese rural dog. Sequence analysis revealed a 2577 nucleotide-long open reading frame of canine TLR5, encoding an 858 amino acid-long protein.
Aihua Zhu, Lingling Wei, Sujuan Hu, Cheng Yang, Caifa Chen, Zhengkun Zhou, Zhiming Pan   +6 more
doaj   +3 more sources

MAP1S controls breast cancer cell TLR5 signaling pathway and promotes TLR5 signaling-based tumor suppression. [PDF]

PLoS ONE, 2014
Targeting TLR5 signaling in breast cancer represents a novel strategy in cancer immunotherapy. However, the underlying mechanism by which TLR5 signaling inhibits cancer cell proliferation and tumor growth has not been elucidated.
Ming Shi, Yuanfei Yao, Fang Han, Yiqun Li, Yu Li   +4 more
doaj   +4 more sources

TLR5 Supports Development of Placental Labyrinthine Zone in Mice [PDF]

Frontiers in Cell and Developmental Biology, 2021
Toll plays an important role in innate immunity and embryonic development in lower-ranked animals, but in mammals, the homolog toll-like receptors (TLR) are reported to facilitate postnatal development of immunity only. Here, we discovered a role of TLR5
Jensen H. C. Yiu, Jensen H. C. Yiu, Samson W. M. Cheung, Samson W. M. Cheung, Jieling Cai, Jieling Cai, Kam-Suen Chan, Jing Chen, Jing Chen, Lai Yee Cheong, Lai Yee Cheong, Hau-Tak Chau, Hau-Tak Chau, Aimin Xu, Aimin Xu, Aimin Xu, Raymond H. W. Li, Connie W. Woo, Connie W. Woo   +18 more
doaj   +3 more sources

T4SS-dependent TLR5 activation by Helicobacter pylori infection [PDF]

Nature Communications, 2019
Toll-like receptor TLR5 recognizes a domain, D1, that is present in flagellins of several pathogenic bacteria but not in Helicobacter pylori. Here, the authors show that TLR5 can be activated independently of flagellin by a component of the H.
Suneesh Kumar Pachathundikandi, Nicole Tegtmeyer, Isabelle Catherine Arnold, Judith Lind, Matthias Neddermann, Christina Falkeis-Veits, Sujay Chattopadhyay, Mark Brönstrup, Werner Tegge, Minsun Hong, Heinrich Sticht, Michael Vieth, Anne Müller, Steffen Backert   +13 more
doaj   +5 more sources

TRIF Modulates TLR5-dependent Responses by Inducing Proteolytic Degradation of TLR5 [PDF]

Journal of Biological Chemistry, 2010
Proteolytic modification of pattern recognition receptors and their signaling adaptor molecules has recently emerged as an essential cellular event to regulate immune and inflammatory responses. Here we show that the TIR domain containing adaptor-inducing interferon-beta (TRIF), an adaptor molecule mediating TLR3 signaling and MyD88-independent ...
Yoon Jeong, Choi, Eunok, Im, Charalabos, Pothoulakis, Sang Hoon, Rhee   +3 more
openaire   +2 more sources

TLR5 Stops Commensals in Their Tracks [PDF]

Cell Host & Microbe, 2013
IgA antibodies help maintain intestinal immune homeostasis with resident commensal species; however, the precise mechanisms regulating IgA induction and the epitopes recognized by these antibodies remain incompletely understood. In this issue of Cell Host & Microbe, Tyler et al.
Koch, Meghan A., Barton, Gregory M.
openaire   +2 more sources

Deglycosylation of eukaryotic-expressed flagellin restores adjuvanticity

npj Vaccines, 2023
Flagellin, the TLR5 agonist, shows potent adjuvant activities in diverse vaccines and immunotherapies. Vibrio vulnificus flagellin B expressed in eukaryotic cells (eFlaB) could not stimulate TLR5 signaling. Enzymatic deglycosylation restored eFlaB’s TLR5
Koemchhoy Khim, Sao Puth, Kamalakannan Radhakrishnan, Tien Duc Nguyen, Youn Suhk Lee, Che-Hun Jung, Shee Eun Lee, Joon Haeng Rhee   +7 more
doaj   +1 more source

Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella

Frontiers in Immunology, 2020
Leptospira (L.) interrogans are invasive bacteria responsible for leptospirosis, a worldwide zoonosis. They possess two periplasmic endoflagellae that allow their motility. L. interrogans are stealth pathogens that escape the innate immune recognition of
Marion Holzapfel, Marion Holzapfel, Marion Holzapfel, Delphine Bonhomme, Delphine Bonhomme, Delphine Bonhomme, Delphine Bonhomme, Julie Cagliero, Frédérique Vernel-Pauillac, Frédérique Vernel-Pauillac, Frédérique Vernel-Pauillac, Martine Fanton d’Andon, Martine Fanton d’Andon, Martine Fanton d’Andon, Sophia Bortolussi, Sophia Bortolussi, Sophia Bortolussi, Laurence Fiette, Cyrille Goarant, Elsio A. Wunder, Elsio A. Wunder, Mathieu Picardeau, Albert I. Ko, Albert I. Ko, Dirk Werling, Mariko Matsui, Ivo G. Boneca, Ivo G. Boneca, Ivo G. Boneca, Catherine Werts, Catherine Werts, Catherine Werts   +31 more
doaj   +1 more source

Structural Basis of TLR5-Flagellin Recognition and Signaling [PDF]

Science, 2012
Flagellin Takes Its Toll The immune system recognizes bacterial infections by binding to conserved molecular fragments derived from the invading bacteria. Molecular mimics of these bacterial determinants have the potential to boost the immunogenicity of vaccines. Yoon
Sung-il, Yoon, Oleg, Kurnasov, Venkatesh, Natarajan, Minsun, Hong, Andrei V, Gudkov, Andrei L, Osterman, Ian A, Wilson   +6 more
openaire   +7 more sources

Role of TLR5 in the Translocation and Dissemination of Commensal Bacteria in the Intestine after Traumatic Hemorrhagic Shock

Journal of Immunology Research, 2021
Enterogenous infection is a major cause of death during traumatic hemorrhagic shock (THS). It has been reported that Toll-like receptor 5 (TLR5) plays an integral role in regulating mucosal immunity and intestinal homeostasis of the microbiota.
Yun Zhang, Jian Zhang, Tao Xu, Cheng Zhang, Wen-Qiao Yu, Tao Wei, Bo Zhang, Qi Chen, Jun-Yu Qiu, Hai-Jun Li, Ting-Bo Liang   +10 more
doaj   +1 more source