Role of Toll-Like Receptor 5 in the Development of Ulcerative Colitis [PDF]
Archives of Razi Institute, 2021 Inflammatory bowel disease (ulcerative colitis and Crohn’s disease) is a remitting and relapsing disease that affects millions of people worldwide. In the intestine, homeostasis between repair and signaling of the proinflammatory of the immune system is ...
A Falah Alshimerry +2 more
doaj +4 more sources
Charge-dependent localization of Toll-like receptor 5 at the plasma membrane [PDF]
Molecules and Cells: Proper subcellular localization of Toll-like receptors (TLRs) is essential for initiating appropriate innate immune responses against pathogens while avoiding self-reactivity.
Ji-Won Huh +4 more
doaj +5 more sources
Toll-like receptor 5 on monocyte as a biomarker of mortality risk in patients with sepsis [PDF]
BMC Infectious DiseasesObjective To evaluate the expression of Toll-like receptor 5 on monocyte at ICU admission as a potentially novel early screening biomarker to predict the mortality risk of sepsis.
Hong Tan +4 more
doaj +4 more sources
Toll-like receptor 5 tunes hepatic and pancreatic stellate cells activation [PDF]
BMJ Open Gastroenterology, 2023 Objective Stellate cells are responsible for liver and pancreas fibrosis and strictly correlate with tumourigenesis. Although their activation is reversible, an exacerbated signalling triggers chronic fibrosis.
Malte Buchholz +6 more
doaj +2 more sources
Toll-like receptor 5-mediated signaling enhances liver regeneration in mice [PDF]
Military Medical Research, 2021 Background Toll-like receptor 5 (TLR5)-mediated pathways play critical roles in regulating the hepatic immune response and show hepatoprotective effects in mouse models of hepatic diseases.
Wen Zhang +14 more
doaj +2 more sources
miR‐155‐regulated mTOR and Toll‐like receptor 5 in gastric diffuse large B‐cell lymphoma [PDF]
Cancer Medicine, 2022 Background Gastric diffuse large B‐cell lymphoma (DLBCL) is often associated with Helicobacter pylori (H. pylori) infection. Those in the early stage could be treated with H.
Wei‐Ting Huang +3 more
doaj +2 more sources
Clinical evaluation of toll-like receptor-5 agonist for radiation-induced oral mucositis in beagle dogs [PDF]
Frontiers in Veterinary Science, 2022 This study aimed to evaluate the clinical safety and validate the radiomitigative effect of KMRC011, against radiation-induced oral mucositis in beagle dogs.
Jaeeun Ko +9 more
doaj +2 more sources
Genome-wide identification and characterization of toll-like receptor 5 (TLR5) in fishes [PDF]
Frontiers in Genetics, 2023 Toll-like receptors 5 (TLR5), a member of the toll-like receptors (TLRs) family, is a class of pattern recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs).
Kai Zhang +10 more
doaj +2 more sources
A deimmunized and pharmacologically optimized Toll-like receptor 5 agonist for therapeutic applications [PDF]
Communications Biology, 2021 Mett et al. describe development of GP532, a substantially deimmunized derivative of Toll-like receptor 5 (TLR5) agonist entolimod. GP532 has mutations eliminating key B- and T-cell epitopes and an inflammasome-activating domain yet remains a potent NF ...
Vadim Mett +13 more
doaj +2 more sources
Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury [PDF]
Acta Neuropathologica Communications, 2020 Microglia are the primary immune-competent cells of the central nervous system (CNS) and sense both pathogen- and host-derived factors through several receptor systems including the Toll-like receptor (TLR) family.
Masataka Ifuku +11 more
doaj +2 more sources