Results 21 to 30 of about 245,171 (291)

Bacterial flagellin is a dominant, stable innate immune activator in the gastrointestinal contents of mice and rats

Gut Microbes, 2023
Intestinal contents comprise the largest repository of immunogenic ligands of microbial origin. We undertook this study to assess the predominant microbe-associated molecular patterns (MAMPs) present therein and the receptors) that mediate the innate ...
Matam Vijay-Kumar, Venugopal R. Bovilla, Beng San Yeoh, Rachel M. Golonka, Piu Saha, Bina Joe, Andrew T. Gewirtz   +6 more
doaj   +1 more source

Role of Toll-Like Receptor 5 (TLR5) in Experimental Melioidosis. [PDF]

Infect Immun, 2019
The Gram-negative intracellular pathogen Burkholderia pseudomallei is the causative agent of melioidosis, an important cause of sepsis in Southeast Asia. Recognition of pathogen-associated molecular patterns by Toll-like receptors (TLRs) is essential for an appropriate immune response during pathogen invasion.
Birnie E, Weehuizen TAF, Lankelma JM, de Jong HK, Koh GCKW, van Lieshout MHP, Roelofs JJTH, Budding AE, de Vos AF, van der Poll T, Wiersinga WJ.   +10 more
europepmc   +5 more sources

Toll‐like receptor 5 and 8 in hepatocellular carcinoma

APMIS, 2021
AbstractToll‐like receptors (TLRs) are components of innate immunity, but also have a role in carcinogenesis. The prognostic value of TLR5 and TLR8 tumor expression was examined in contrast with known risk markers Ki67 and p53. All HCC patients from Oulu University Hospital with available representative tumor sample were included in this study (n = 182)
Huhta Heikki, Kemi Niko Aleksi, Helminen Olli, Kairaluoma Valtteri Mattias, Pohjanen Vesa-Matti, Huhta Heikki   +5 more
openaire   +3 more sources

Toll-like receptor 5 as a novel receptor for fungal zymosan [PDF]

, 2021
Microbial pathogens carry specific structural patterns which were termed pathogen-associated molecular patterns (PAMPs). Toll-like receptors (TLRs) as key elements for the recognition of microbial pathogens are necessary for the activation of innate immune pathways.
Stefanie Reuter, Kristina Herold, Jana Domrös, Ralf Mrowka   +3 more
openaire   +1 more source

3-(5-Hydroxyphenyl)-5-Phenyl-2-Pyrazolines as Toll-Like Receptor 7 Agonists

Journal of Chemistry, 2023
Toll-like receptor 7 (TLR7) is an attractive target for developing immune modulators to enhance innate immunity against ssRNA virus infections, including hepatitis C and COVID-19.
Ji Hwan Kim, Seunghyun Ahn, Dongsoo Koh, Young Han Lee, Yoongho Lim, Soon Young Shin   +5 more
doaj   +1 more source

Evasion of Toll-like receptor 5 by flagellated bacteria [PDF]

Proceedings of the National Academy of Sciences, 2005
Toll-like receptor 5 (TLR5) recognizes an evolutionarily conserved site on bacterial flagellin that is required for flagellar filament assembly and motility. The α and ε Proteobacteria , including the important human pathogens Campylobacter jejuni ,
Andersen-Nissen, Erica, Smith, Kelly D., Strobe, Katie L., Barrett, Sara L. Rassoulian, Cookson, Brad T., Logan, Susan M., Aderem, Alan   +6 more
openaire   +2 more sources

The expression of Toll-like receptor 5 in preterm histologic chorioamnionitis. [PDF]

J Clin Biochem Nutr, 2018
Spontaneous preterm birth is often caused by chorioamnionitis. Toll-like receptors (TLRs) have a role in the response of the innate immune system. The role of TLR5 in chorioamnionitis remains unclear: however, TLR5 was reported to have a significantly stronger effect on the induction of interleukin (IL)-6 when compared with other TLRs in amniotic ...
Moroi H, Kotani T, Miki R, Tsuda H, Mizuno M, Ito Y, Ushida T, Imai K, Nakano T, Li H, Sumigama S, Yamamoto E, Iwase A, Kikkawa F.   +13 more
europepmc   +4 more sources

Toll-like receptor 5 and Toll-like receptor 9 single nucleotide polymorphisms and risk of systemic lupus erythematosus and nephritis in Egyptian patients

Egyptian Rheumatology and Rehabilitation, 2021
Background Toll-like (TLRs) play a crucial role in both adaptive and innate immunity. The aim of the present study was to assess the association of TLR5-rs5744168, TLR9-rs187084, and TLR9-rs352140 single nucleotide polymorphisms (SNPs) with ...
Ola Mohammad Gharbia, Sherine Abdel Rahman Bassiouni, Maysaa El Sayed Zaki, Shimaa Mohsen El-Beah, Manal Mohamed El-Desoky, Eman Adel Elmansoury, Mostafa Abdelsalam   +6 more
doaj   +1 more source

Flagellin Alleviates Airway Allergic Response by Stabilizing Eosinophils through Modulating Oxidative Stress

Journal of Innate Immunity, 2021
Eosinophil (Eo) degranulation plays a central role in the initiations of allergic attacks. Flagellin (FGN), the major component of bacterial flagella, has immune regulatory functions.
Xiang-Qian Luo, Jun Liu, Li-Hua Mo, Gui Yang, Fei Ma, Yan Ning, Ping-Chang Yang, Da-Bo Liu   +7 more
doaj   +1 more source

Clostridium butyricum Helps to Alleviate Inflammation in Weaned Piglets Challenged With Enterotoxigenic Escherichia coli K88

Frontiers in Veterinary Science, 2021
Background: Whether the probiotic Clostridium butyricum (CB) alleviates enterotoxigenic Escherichia coli (ETEC) K88-induced inflammation by regulating the activation of the toll-like receptor (TLR) signaling pathway is not clear, thus, we carried out ...
Haihua Li, Xuejiao Liu, Zhiyuan Shang, Jiayun Qiao   +3 more
doaj   +1 more source