Results 21 to 30 of about 219,856 (143)
A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin [PDF]
Journal of Experimental Medicine, 2007 The molecular basis for Toll-like receptor (TLR) recognition of microbial ligands is unknown. We demonstrate that mouse and human TLR5 discriminate between different flagellins, and we use this difference to map the flagellin recognition site on TLR5 to 228 amino acids of the extracellular domain.
Roland Strong +2 more
exaly +3 more sources
Therapeutic Synergy Between Antibiotics and Pulmonary Toll-Like Receptor 5 Stimulation in Antibiotic-Sensitive or -Resistant Pneumonia [PDF]
Frontiers in Immunology, 2019 Bacterial infections of the respiratory tract constitute a major cause of death worldwide. Given the constant rise in bacterial resistance to antibiotics, treatment failure is increasingly frequent.
Laura Matarazzo +7 more
doaj +2 more sources
Exploring the mechanism of intestinal bacterial translocation after severe acute pancreatitis: the role of Toll-like receptor 5 [PDF]
Gut MicrobesSevere acute pancreatitis (SAP)-induced intestinal bacterial translocation and enterogenic infection are among the leading causes of mortality in patients.
Cheng Zhang +9 more
doaj +2 more sources
Gut Microbes, 2023 Intestinal contents comprise the largest repository of immunogenic ligands of microbial origin. We undertook this study to assess the predominant microbe-associated molecular patterns (MAMPs) present therein and the receptors) that mediate the innate ...
Matam Vijay-Kumar +6 more
doaj +1 more source
Toll‐like receptor 5 and 8 in hepatocellular carcinoma
APMIS, 2021 AbstractToll‐like receptors (TLRs) are components of innate immunity, but also have a role in carcinogenesis. The prognostic value of TLR5 and TLR8 tumor expression was examined in contrast with known risk markers Ki67 and p53. All HCC patients from Oulu University Hospital with available representative tumor sample were included in this study (n = 182)
Huhta Heikki +5 more
openaire +3 more sources
3-(5-Hydroxyphenyl)-5-Phenyl-2-Pyrazolines as Toll-Like Receptor 7 Agonists
Journal of Chemistry, 2023 Toll-like receptor 7 (TLR7) is an attractive target for developing immune modulators to enhance innate immunity against ssRNA virus infections, including hepatitis C and COVID-19.
Ji Hwan Kim +5 more
doaj +1 more source
Toll-like receptor 5 as a novel receptor for fungal zymosan [PDF]
, 2021 Microbial pathogens carry specific structural patterns which were termed pathogen-associated molecular patterns (PAMPs). Toll-like receptors (TLRs) as key elements for the recognition of microbial pathogens are necessary for the activation of innate immune pathways.
Stefanie Reuter +3 more
openaire +1 more source
Evasion of Toll-like receptor 5 by flagellated bacteria [PDF]
Proceedings of the National Academy of Sciences, 2005 Toll-like receptor 5 (TLR5) recognizes an evolutionarily conserved site on bacterial flagellin that is required for flagellar filament assembly and motility. The α and ε Proteobacteria , including the important human pathogens Campylobacter jejuni ,
Andersen-Nissen, Erica +6 more
openaire +2 more sources
Egyptian Rheumatology and Rehabilitation, 2021 Background Toll-like (TLRs) play a crucial role in both adaptive and innate immunity. The aim of the present study was to assess the association of TLR5-rs5744168, TLR9-rs187084, and TLR9-rs352140 single nucleotide polymorphisms (SNPs) with ...
Ola Mohammad Gharbia +6 more
doaj +1 more source
Journal of Innate Immunity, 2021 Eosinophil (Eo) degranulation plays a central role in the initiations of allergic attacks. Flagellin (FGN), the major component of bacterial flagella, has immune regulatory functions.
Xiang-Qian Luo +7 more
doaj +1 more source