Results 41 to 50 of about 245,171 (291)

Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn's disease

EBioMedicine, 2022
Summary: Background: Crohn's disease (CD) is a chronic inflammatory disorder characterized by intestinal immune dysfunction. Multiple factors, including gut dysbiosis, are involved in the pathogenesis of CD.
Zhaohua Shen, Weiwei Luo, Bei Tan, Kai Nie, Minzi Deng, Shuai Wu, Mengwei Xiao, Xing Wu, Xiangrui Meng, Ting Tong, Chao Zhang, Kejia Ma, Yangjie Liao, Jiahao Xu, Xiaoyan Wang   +14 more
doaj   +1 more source

Modulation of Toll-like receptor activity by leukocyte Ig-like receptors and their effects during bacterial infection. [PDF]

, 2010
Toll-like receptors (TLRs) are a potent trigger for inflammatory immune responses. Without tight regulation their activation could lead to pathology, so it is imperative to extend our understanding of the regulatory mechanisms that govern TLR expression ...
Martin Vordermeier, Allen, RL, Rachel L. Allen, Pilsbury, LE, Louise E. Pilsbury, Vordermeier, M   +5 more
core   +1 more source

Toll-like receptor signaling and SIGIRR in renal fibrosis upon unilateral ureteral obstruction. [PDF]

, 2011
Innate immune activation via IL-1R or Toll-like receptors (TLR) contibutes to acute kidney injury but its role in tissue remodeling during chronic kidney disease is unclear.
Skuginna Veronika, Mantovani Alberto, S. Clauss, Heni Eka Susanti, R. Allam, Skuginna, Veronika, Clauss, Sebastian, Susanti, Heni Eka, Ramanjaneyulu Allam, H. E. Susanti, Hans-Joachim Anders, Christoph Römmele, Sebastian Clauss, M. Lech, Veronika Skuginna, Clauss Sebastian, Cecilia Garlanda, Lech, Maciej, Ryu, Mi, Lech Maciej, Garlanda Cecilia, C. Garlanda, Ryu Mi, Römmele, Christoph, Heni Eka, Mantovani, Alberto, Alberto Mantovani, Anders Hans-Joachim, Allam Ramanjaneyulu, Maciej Lech, Cecilia Garl, M. Ryu, Susanti Heni Eka, A. Mantovani, Anders, Hans-Joachim, Mi Ryu, Allam, Ramanjaneyulu, Römmele Christoph, C. Römmele, H. J. Anders, Garlanda, Cecilia, V. Skuginna   +41 more
core   +1 more source

Infection-induced 5'-half molecules of tRNAHisGUG activate Toll-like receptor 7.

PLoS Biology, 2020
Toll-like receptors (TLRs) play a crucial role in the innate immune response. Although endosomal TLR7 recognizes single-stranded RNAs, their endogenous RNA ligands have not been fully explored.
Kamlesh Pawar, Megumi Shigematsu, Soroush Sharbati, Yohei Kirino   +3 more
doaj   +1 more source

Restoration of 5-methoxytryptophan protects against atherosclerotic chondrogenesis and calcification in ApoE −/− mice fed high fat diet

Journal of Biomedical Science, 2021
Background Toll-like receptor-2 (TLR2) promotes vascular smooth muscle cell (VSMC) transdifferentiation to chondrocytes and calcification in a p38 MAPK-dependent manner.
Guan-Lin Lee, Tsai-Lien Liao, Jing-Yiing Wu, Kenneth K. Wu, Cheng-Chin Kuo   +4 more
doaj   +1 more source

Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation. [PDF]

, 2015
Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory diseases. Although the role of toll-like receptor 4 (TLR4) in microglia's inflammatory response is fully acknowledged, little is ...
Martina Svensson, Osman, AM, Salomonsson, E, Oliva Martín, María José, Annette Persson, Burguillos García, Miguel Ángel, Garcia-Quintanilla, Albert, Nikenza Viceconte, Englund, Elisabet,, Schulte, Tim, Elisabet Englund, Schulte, Tim,, Albert Garcia-Quintanilla, Kavanagh, Edel, Ahmed Mohamed Osman, Santiago, M, Joseph, Bertrand, García-Quintanilla, Alberto, Amar, Lahouari, Deierborg, Tomas,, Persson, A, Venero, Jose Luis, Blomgren, Klas, Englund, E, Leffler, H, Jose Luis Venero, Boza Serrano, Antonio, Burguillos, MA, García Quintanilla, Alberto, Martiniano Santiago, Antonio Boza-Serrano, Hakon Leffler, Joseph, B, Deierborg, Tomas, Englund, Elisabet, Persson, Annette,, Amar, L, Edel Kavanagh, Kavanagh, E, Lund University., Leffler, Hakon,, Emma Salomonsson, Venero, JL, Boza Serrano, Antonio,, Santiago, Martiniano, Venero Recio, José Luis, Amar, Lahouari,, Kavanagh, Edel T., Oliva-Martín, María J., Blomgren, K, Svensson, Martina,, Miguel Angel Burguillos, Viceconte, Nikenza, Bertrand Joseph, Salomonsson, Emma,, Oliva-Martin, Maria Jose, Svensson, Martina, Tim Schulte, Maria Jose Oliva-Martin, Osman, Ahmed Mohamed, Oliva-Martin, MJ, Boza-Serrano, A, Salomonsson, Emma, Persson, Annette, Achour, A, Garcia-Quintanilla, A, Adnane Achour, Achour, Adnane, Burguillos Garcia, Miguel, Viceconte, N, Burguillos Garcia, Miguel,, Santiago Pavón, Martiniano, Schulte, T, Tomas Deierborg, Svensson, M, Venero, José L., Klas Blomgren, Lahouari Amar, Deierborg, T, Burguillos, Miguel Angel, Leffler, Hakon, Boza-Serrano, Antonio   +81 more
core   +1 more source

Flagellin A Toll-Like Receptor 5 Agonist as an Adjuvant in Chicken Vaccines [PDF]

Clinical and Vaccine Immunology, 2014
ABSTRACTChicken raised under commercial conditions are vulnerable to environmental exposure to a number of pathogens. Therefore, regular vaccination of the flock is an absolute requirement to prevent the occurrence of infectious diseases. To combat infectious diseases, vaccines require inclusion of effective adjuvants that promote enhanced protection ...
Shishir Kumar, Gupta, Preety, Bajwa, Rajib, Deb, Madhan Mohan, Chellappa, Sohini, Dey   +4 more
openaire   +2 more sources

A flagellin-derived toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity. [PDF]

PLoS ONE, 2014
Toll-like receptor (TLR) mediated recognition of pathogen associated molecular patterns allows the immune system to rapidly respond to a pathogenic insult.
Nicholas D Leigh, Guanglin Bian, Xilai Ding, Hong Liu, Semra Aygun-Sunar, Lyudmila G Burdelya, Andrei V Gudkov, Xuefang Cao   +7 more
doaj   +1 more source

Stellate ganglion block reduces inflammation and improves neurological function in diabetic rats during ischemic stroke

Neural Regeneration Research, 2022
Diabetes mellitus is an independent risk factor for ischemic stroke. Both diabetes mellitus and stroke are linked to systemic inflammation that aggravates patient outcomes.
Ting-Ting Li, Qiang Wan, Xin Zhang, Yuan Xiao, Li-Ying Sun, Yu-Rong Zhang, Xiang-Nan Liu, Wan-Chao Yang   +7 more
doaj   +1 more source

Regulation of Toll-like receptor 5 gene expression and function on mucosal dendritic cells. [PDF]

PLoS ONE, 2012
Toll-like receptor (TLR) 5 has been shown to maintain intestinal homeostasis and regulate host defense against enterobacterial infection. However, how TLR5 expression is regulated and its function in the intestine have not been fully elucidated.
Ting Feng, Yingzi Cong, Katie Alexander, Charles O Elson   +3 more
doaj   +1 more source