Distinctive Recognition of Flagellin by Human and Mouse Toll-Like Receptor 5. [PDF]
PLoS ONE, 2016 Toll-like receptor 5 (TLR5) is a receptor of the innate immune system that recognizes flagellin from certain bacterial species and triggers an inflammatory response.
Vida Forstnerič +4 more
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Adaptive evolution of Toll-like receptor 5 in domesticated mammals [PDF]
BMC Evolutionary Biology, 2012 Background Previous studies have proposed that mammalian toll like receptors (TLRs) have evolved under diversifying selection due to their role in pathogen detection.
Smith Sarah A +6 more
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Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. [PDF]
PLoS ONE, 2016 Excessive type 2 helper T cell responses to environmental antigens can cause immunopathology such as asthma and allergy, but how such immune responses are induced remains unclear.
Linda M Lee +9 more
doaj +7 more sources
The role of the C-terminal D0 domain of flagellin in activation of Toll like receptor 5. [PDF]
PLoS Pathogens, 2017 Flagellin is a wide-spread bacterial virulence factor sensed by the membrane-bound Toll-like receptor 5 (TLR5) and by the intracellular NAIP5/NLRC4 inflammasome receptor.
Vida Forstnerič +4 more
doaj +2 more sources
Significant abundance of bacterial flagellin and expression of its surface localized receptor toll-like receptor 5 and cytokine interleukin-22 in South African infants with poor oral rotavirus vaccine take [PDF]
Gut PathogensBacterial flagellin, a potent intestinal innate immune activator, prevents murine rotavirus (RV) infection independent of adaptive immunity and interferons. The flagellin-induced immunity is mediated by Toll-like receptor (TLR5) and Nod-like receptor C4 (
Nontlantla J. Haindongo +2 more
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Activated sympathetic nerve post stroke downregulates Toll-like receptor 5 and disrupts the gut mucosal barrier [PDF]
Cell Reports MedicineSummary: The gut permeability significantly increases after ischemic stroke, partly due to disrupted mucosal barrier, but the mechanism remains elusive.
Huidi Wang +14 more
doaj +2 more sources
In silico study of ligand binding site of toll-like receptor 5
Advanced Biomedical Research, 2014 Background: Toll-like receptor-5 (TLR-5) is a member of TLRs family and responsible for bacterial flagellin recognition. The activation of TLR-5 with flagellin leads to initiation of signaling cascades, which in turn results in transcription of pro ...
Nastaran Sadat Savar, Saeid Bouzari
doaj +3 more sources
Therapeutic Synergy Between Antibiotics and Pulmonary Toll-Like Receptor 5 Stimulation in Antibiotic-Sensitive or -Resistant Pneumonia [PDF]
Frontiers in Immunology, 2019 Bacterial infections of the respiratory tract constitute a major cause of death worldwide. Given the constant rise in bacterial resistance to antibiotics, treatment failure is increasingly frequent.
Laura Matarazzo +7 more
doaj +2 more sources
Exploring the mechanism of intestinal bacterial translocation after severe acute pancreatitis: the role of Toll-like receptor 5 [PDF]
Gut MicrobesSevere acute pancreatitis (SAP)-induced intestinal bacterial translocation and enterogenic infection are among the leading causes of mortality in patients.
Cheng Zhang +9 more
doaj +2 more sources
Genetic diversity of Toll-like receptor 5 among pig populations [PDF]
Genetics and Molecular Biology, 2013 The Toll-like receptor 5 (TLR5) recognizes flagellin of Gram-positive and -negative bacteria and plays an important role in the host defense system. Here, we surveyed single nucleotide polymorphisms (SNPs) in the coding sequence of the porcine TLR5 gene ...
Xiuqin Yang +3 more
doaj +5 more sources