Results 11 to 20 of about 16,836,737 (243)

Genome-wide identification and characterization of toll-like receptor 5 (TLR5) in fishes [PDF]

Frontiers in Genetics, 2023
Toll-like receptors 5 (TLR5), a member of the toll-like receptors (TLRs) family, is a class of pattern recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs).
Kai Zhang, Kai Zhang, Ming Chen, Ming Chen, Haobin He, Hongyan Kou, Hongyan Kou, Li Lin, Li Lin, Rishen Liang, Rishen Liang   +10 more
doaj   +2 more sources

Toll-like receptor 5 on monocyte as a biomarker of mortality risk in patients with sepsis [PDF]

BMC Infectious Diseases
Objective To evaluate the expression of Toll-like receptor 5 on monocyte at ICU admission as a potentially novel early screening biomarker to predict the mortality risk of sepsis.
Hong Tan, Hanyi Wang, Xuanyi Zhou, Wenjun Que, Xiaoliang Yang   +4 more
doaj   +2 more sources

Charge-dependent localization of Toll-like receptor 5 at the plasma membrane [PDF]

Molecules and Cells
: Proper subcellular localization of Toll-like receptors (TLRs) is essential for initiating appropriate innate immune responses against pathogens while avoiding self-reactivity.
Ji-Won Huh, Kwangcheon Park, Hyun-Sup Song, Seongryong Kim, You-Me Kim   +4 more
doaj   +2 more sources

A deimmunized and pharmacologically optimized Toll-like receptor 5 agonist for therapeutic applications [PDF]

Communications Biology, 2021
Mett et al. describe development of GP532, a substantially deimmunized derivative of Toll-like receptor 5 (TLR5) agonist entolimod. GP532 has mutations eliminating key B- and T-cell epitopes and an inflammasome-activating domain yet remains a potent NF ...
Vadim Mett, Oleg V. Kurnasov, Ivan A. Bespalov, Ivan Molodtsov, Craig M. Brackett, Lyudmila G. Burdelya, Andrei A. Purmal, Anatoli S. Gleiberman, Ilia A. Toshkov, Catherine A. Burkhart, Yakov N. Kogan, Ekaterina L. Andrianova, Andrei V. Gudkov, Andrei L. Osterman   +13 more
doaj   +2 more sources

Distinctive Recognition of Flagellin by Human and Mouse Toll-Like Receptor 5. [PDF]

PLoS ONE, 2016
Toll-like receptor 5 (TLR5) is a receptor of the innate immune system that recognizes flagellin from certain bacterial species and triggers an inflammatory response.
Vida Forstnerič, Karolina Ivičak-Kocjan, Ajasja Ljubetič, Roman Jerala, Mojca Benčina   +4 more
doaj   +2 more sources

Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury [PDF]

Acta Neuropathologica Communications, 2020
Microglia are the primary immune-competent cells of the central nervous system (CNS) and sense both pathogen- and host-derived factors through several receptor systems including the Toll-like receptor (TLR) family.
Masataka Ifuku, Lukas Hinkelmann, Leonard D. Kuhrt, Ibrahim E. Efe, Victor Kumbol, Alice Buonfiglioli, Christina Krüger, Philipp Jordan, Marcus Fulde, Mami Noda, Helmut Kettenmann, Seija Lehnardt   +11 more
doaj   +2 more sources

Significant abundance of bacterial flagellin and expression of its surface localized receptor toll-like receptor 5 and cytokine interleukin-22 in South African infants with poor oral rotavirus vaccine take [PDF]

Gut Pathogens
Bacterial flagellin, a potent intestinal innate immune activator, prevents murine rotavirus (RV) infection independent of adaptive immunity and interferons. The flagellin-induced immunity is mediated by Toll-like receptor (TLR5) and Nod-like receptor C4 (
Nontlantla J. Haindongo, Mapaseka Seheri, Cliff A. Magwira   +2 more
doaj   +2 more sources

Activated sympathetic nerve post stroke downregulates Toll-like receptor 5 and disrupts the gut mucosal barrier [PDF]

Cell Reports Medicine
Summary: The gut permeability significantly increases after ischemic stroke, partly due to disrupted mucosal barrier, but the mechanism remains elusive.
Huidi Wang, Jie Li, Guangyan Wu, Xiaofei Lin, Jiaying Chen, Jingru Liang, Jiahui Zhang, Xiaoxia Luo, Hongyun Mao, Jiahui Xie, Zhuang Li, Hongwei Zhou, Kaiyu Xu, Jia Yin, Yan He   +14 more
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Therapeutic Synergy Between Antibiotics and Pulmonary Toll-Like Receptor 5 Stimulation in Antibiotic-Sensitive or -Resistant Pneumonia [PDF]

Frontiers in Immunology, 2019
Bacterial infections of the respiratory tract constitute a major cause of death worldwide. Given the constant rise in bacterial resistance to antibiotics, treatment failure is increasingly frequent.
Laura Matarazzo, Fiordiligie Casilag, Rémi Porte, Frederic Wallet, Delphine Cayet, Christelle Faveeuw, Christophe Carnoy, Jean-Claude Sirard   +7 more
doaj   +2 more sources

Exploring the mechanism of intestinal bacterial translocation after severe acute pancreatitis: the role of Toll-like receptor 5 [PDF]

Gut Microbes
Severe acute pancreatitis (SAP)-induced intestinal bacterial translocation and enterogenic infection are among the leading causes of mortality in patients.
Cheng Zhang, Shiyin Chen, Zhien Wang, Jian Zhang, Wenqiao Yu, Yanshuai Wang, Weiwei Si, Yuwei Zhang, Yun Zhang, Tingbo Liang   +9 more
doaj   +2 more sources