Results 41 to 50 of about 16,392 (208)
Flagellin as a vaccine adjuvant
Expert Review of Vaccines, 2018 Introduction: Bacterial flagellin, as a pathogen-associated molecular pattern (PAMP), can activate both innate and adaptive immunity. Its unique structural characteristics endow an effective and flexible adjuvant activity, which allow the design of ...
Baofeng Cui +5 more
doaj +1 more source
The N‐terminal D1 domain of Treponema pallidum flagellin binding to TLR5 is required but not sufficient in activation of TLR5 [PDF]
Journal of Cellular and Molecular Medicine, 2019 AbstractSyphilis is a chronic bacterial infection caused by Treponema pallidum (T pallidum) and the pathogenesis that T pallidum infection induces immunopathological damages in skin and other tissues remains unclear. We have previously reported that recombinant flagellins of T pallidum can elicit IL‐6 and IL‐8 transcriptions via TLR5 pathway.
Man Xu +8 more
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Acta Neuropathologica Communications, 2020 Microglia are the primary immune-competent cells of the central nervous system (CNS) and sense both pathogen- and host-derived factors through several receptor systems including the Toll-like receptor (TLR) family.
Masataka Ifuku +11 more
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Deletion of TLR5 results in spontaneous colitis in mice [PDF]
Journal of Clinical Investigation, 2007 Activation of TLRs by bacterial products results in rapid activation of genes encoding products designed to protect the host from perturbing microbes. In the intestine, which is colonized by a large and diverse population of commensal bacteria, TLR signaling may not function in a simple on/off mode. Here, we show that the flagellin receptor TLR5 has an
Matam, Vijay-Kumar +10 more
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TLR5 Signaling in the Regulation of Intestinal Mucosal Immunity
Journal of Inflammation Research, 2023 Toll-like receptor 5 (TLR5) is a pattern recognition receptor that specifically recognizes flagellin and consequently plays a crucial role in the control of intestinal homeostasis by activating innate and adaptive immune responses. TLR5 overexpression, on the other hand, might disrupt the intestinal mucosal barrier, which serves as the first line of ...
Feng,Shuyan +5 more
openaire +4 more sources
The role of the C-terminal D0 domain of flagellin in activation of Toll like receptor 5. [PDF]
PLoS Pathogens, 2017 Flagellin is a wide-spread bacterial virulence factor sensed by the membrane-bound Toll-like receptor 5 (TLR5) and by the intracellular NAIP5/NLRC4 inflammasome receptor.
Vida Forstnerič +4 more
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Figure 1 | Comparing Toll-like Receptor 5 (TLR5) Domains Using HMMER
, 2022 Figure 1 | Comparing Toll-like Receptor 5 (TLR5) Domains using HMMERHMMER - EMBL - EBI results for TLR5, soluble TLR5 (sTLR5), and potentially soluble forms of TLR5 ((s)TLR5) for the following species: Salmo salar, Salmo trutta, Oncorhynchus tshawytscha,
Elizabeth Ramirez (12218378) +3 more
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TLR5 signaling enhances the proliferation of human allogeneic CD40-activated B cell induced CD4hiCD25+ regulatory T cells. [PDF]
PLoS ONE, 2013 Although diverse functions of different toll-like receptors (TLR) on human natural regulatory T cells have been demonstrated recently, the role of TLR-related signals on human induced regulatory T cells remain elusive.
Ping-Lung Chan +9 more
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Frontiers in Immunology, 2021 Vibrio anguillarum, an opportunistic pathogen of aquatic animals, moves using a filament comprised of polymerised flagellin proteins. Flagellins are essential virulence factors for V. anguillarum infection.
Quanxin Gao +11 more
doaj +1 more source
, 2013 Frequency and significance of the TLR5 G22A, TLR5 C100T and TLR5 T1844C single nucleotide polymorphism genotype in a case-control association study in German shepherd dogs (GSDs) with inflammatory bowel disease using a SNaPSHOT multiplex reaction (case =
Karin Allenspach (335040) +6 more
core +1 more source