Results 51 to 60 of about 16,392 (208)
Acta Pharmaceutica Sinica B, 2021 Salmonella: mediated cancer therapy has achieved remarkable anti-tumor effects in experimental animal models, but the detailed mechanism remains unsolved. In this report, the active involvement of the host immune response in this process was confirmed by
Jianxiang Chen +8 more
doaj +1 more source
Common TLR5 Mutations Control Cancer Progression
Cancer Cell, 2015 The mechanisms regulating tumor-associated inflammation are incompletely understood. In this issue of Cancer Cell, Rutkowski and colleagues indicate that TLR5 signaling deficiency, which occurs in ∼10% of the population, changes interactions with commensal microbiota and deregulates a cascade of inflammatory events that can suppress or accelerate ...
Pfirschke, Christina +2 more
openaire +3 more sources
Медицинская иммунологияPseudomonas aeruginosa, an opportunistic pathogen of considerable clinical import, presents a formidable challenge to susceptible individuals, particularly within the confines of nosocomial settings.
Muslim Idan Mohsin +6 more
doaj +1 more source
Figure 2 | Phylogenetic Tree based on Toll-like Receptor 5 (TLR5) CDS
, 2022 Figure 2 | Phylogenetic Tree based on Toll-like Receptor 5 (TLR5) CDSPhylogenetic tree analysis based on CDS of TLR5, soluble TLR5 (sTLR5), and potentially soluble TLR5 ((s)TLR5) found in the following species: Salmo salar, Salmo trutta, Oncorhynchus ...
Elizabeth Ramirez (12218378) +3 more
core +1 more source
Elevated TLR5 expression in vivo and loss of NF-kappa B activation via TLR5 in vitro detected in HPV-negative oropharyngeal squamous cell carcinoma [PDF]
, 2020 In oropharyngeal squamous cell carcinoma (OPSCC), the expression pattern of toll-like receptors (TLRs), in comparison between human papillomavirus (HPV)-positive and -negative tumors differs.
Kylmä, Anna Kaisa +10 more
core +1 more source
TLR5 Activation Exacerbates Airway Inflammation in Asthma
Lung, 2020 Innate immune activation through exposure to indoor and outdoor pollutants is emerging as an important determinant of asthma severity. For example, household levels of the bacterial product lipopolysaccharide (LPS) are associated with increased asthma severity.
G. S. Whitehead +7 more
openaire +3 more sources
Modulation of Animal Gut Health by Milk Oligosaccharide
Animal Research and One Health, EarlyView.This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen +7 more
wiley +1 more source
Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn's disease
EBioMedicine, 2022 Summary: Background: Crohn's disease (CD) is a chronic inflammatory disorder characterized by intestinal immune dysfunction. Multiple factors, including gut dysbiosis, are involved in the pathogenesis of CD.
Zhaohua Shen +14 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik +3 more
wiley +1 more source
PLoS Neglected Tropical Diseases, 2019 BackgroundToll-like receptors (TLRs) are sentinel receptors of the innate immune system. TLR4 detects bacterial lipopolysaccharide (LPS) and TLR5 detects bacterial flagellin.
Amy K Dickey +11 more
doaj +1 more source